SHAILENDRA PRATAP SINGH
central university of Rajsthan, New York Medical College, Indian Institute of Chemical Technology (JNTUH), Indian Institute of Chemical Technology
0000-0003-2996-0374
About
Dr. Shailendra Singh
Assistant Professor
Central University of Rajasthan, India
Visiting Professor
New York Medical College, New York, USA
Former Research Scientist
New York Medical College, New York, USA )++91-8287230934 (India) * [email protected]
India Address: S-39 Mitra Niwas Colony, Madanganj, Kishangarh, Ajmer, Rajasthan
RESEARCH EXPERTISE
My research aims to identify a novel target and the underlying molecular mechanisms that control metabolic rate, oxygen consumption, and insulin sensitivity not only in skeletal muscle but also in cardiac muscle and in adipose tissue normally as well as during sports/exercise. PGC-1a is implicated in the activation of genes involved in fatty acid oxidation and mitochondrial biogenesis, as well as the upregulation of GLUT4 expression in muscle cells. The mitochondrial respiratory chain is the means by which ATP is generated within mitochondria, the cellular powerhouses. The conversion of NAD+ and FAD to NADH and FAD begins with acetyl-coenzyme A (CoA), which can be made from fatty acids, amino acids, or the oxidation of pyruvate. The creation of cellular energy depends on the proper functioning of this cycle. Transporting electrons from NADH and FADH to the ETC complexes aids in proton transport across the inner mitochondrial membrane, which in turn fuels ATP synthesis.
VISITING PROFESSOR:
• Visiting professor at the Centre for Higher Studies in Human and Health Sciences at the Inter-American Open University in Buenos Aires, Argentina
• Visiting professor at the Petrovsky National Research Center of Surgery, Russia, Moscow
Employment
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central university of Rajsthan ASSISTANT PROFESSOR2020 - Present
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New York Medical College RESEARCH SCIENTIST2015 - 2019
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Indian Institute of Chemical Technology PHD2007 - 2013
Education
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Indian Institute of Chemical Technology (JNTUH) PhD2008 - 2013
Projects & Funding
Projects & funding information is unavailable.
Publications (52)
- Development of Edible Carbohydrate–Protein Sports Gels to Optimize the Muscle Glycogen Re-Synthesis Save
- The Role of Gut Microbiota and Associated Compounds in Cardiovascular Health and its Therapeutic Implications Save
- Acetaldehyde and Butyrate: Their Biological Effects on the Liver and the Gut Axis Save
- The Role of the Gut Microbiome and the Hepatic Axis in the Pathogenesis of Metabolic Syndrome and Therapeutics Save
- Apoptotic Cell Death in Cardiomyocytes Induced by Hypoxia from Cobalt Chloride Is Hastened by SGLT-1 Inhibition Save
- Combined effect of yoga and naturopathy in uncomplicated varicose vein disease – a prospective randomized controlled trial Save
- Silencing the Adipocytokine NOV: A Novel Approach to Reversing Oxidative Stress-Induced Cardiometabolic Dysfunction Save
- Adipocyte-Specific Expression of PGC1α Promotes Adipocyte Browning and Alleviates Obesity-Induced Metabolic Dysfunction in an HO-1-Dependent Fashion Save
- SARS-CoV-2 Infections, Impaired Tissue, and Metabolic Health: Pathophysiology and Potential Therapeutics. Save
- Exploring New Drug Targets for Type 2 Diabetes: Success, Challenges and Opportunities Save