Sebastian M. Waszak
École Polytechnique Fédérale de Lausanne, University of California, San Francisco, Weihenstephan-Triesdorf University of Applied Sciences, University of Oslo
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Chromatin Remodeling and Cancer · Glioma Diagnosis and Treatment · Acute Myeloid Leukemia Research
0000-0003-3042-9521
About
Sebastian M. Waszak is a Tenure-Track Assistant Professor of Life Sciences at the École Polytechnique Fédérale de Lausanne and an Associate Adjunct Professor of Neurology at the University of California, San Francisco. He is the Director of the Laboratory of Computational Neuro-Oncology at the Swiss Institute for Experimental Cancer Research. He obtained his PhD in Bioengineering and Biotechnology from the École Polytechnique Fédérale de Lausanne and specialized as a postdoctoral fellow in cancer genomics at the European Molecular Biology Laboratory. His research focuses on biomedical data science for children and young adults with brain tumours. He studies the spatio-temporal evolution of childhood brain tumours and develops computational methods to diagnose and monitor patient responses to therapy. He published 80 papers in basic science and medical journals (h-index 40; >11,000 citations), with first/senior author publications in Science (2013), Cell (2015), The Lancet Oncology (2018), Nature (2020a, 2020b), Clinical Cancer Research (2021), and the Journal of Clinical Oncology (2020, 2023). He contributed and introduced novel entities to the 2021 WHO Classification of CNS Tumors and the 2023 WHO Classification of Genetic Tumor Syndromes. His research resulted in revising clinical practice guidelines and amendments to clinical trial protocols. He is a member of the Pacific Pediatric Neuro-Oncology Consortium, the Pediatric DMG Tumor Board at UCSF, and the DIPG/DMG National Brain Tumor Board.
Employment
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École Polytechnique Fédérale de Lausanne Tenure Track Assistant Professor2023 - Present
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University of California, San Francisco Associate Adjunct Professor2021 - Present
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University of Oslo Group Leader2020 - Present
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European Molecular Biology Laboratory Postdoctoral Fellow2014 - 2019
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École Polytechnique Fédérale de Lausanne Predoctoral Fellow2010 - 2014
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Weizmann Institute of Science Research Assistant2009 - 2009
Education
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École Polytechnique Fédérale de Lausanne Ph.D. in Biotechnology & Bioengineering2010 - 2014
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Hochschule Weihenstephan-Triesdorf Dipl.-Ing. (FH) in Bioinformatics2005 - 2010
Projects & Funding
Projects & funding information is unavailable.
Publications (20)
- Medulloblastoma-Associated KBTBD4 Mutations Disrupt PP2A-A Orphan Quality Control Save
- Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric CNS tumors Save
- Somatic CpG hypermutation is associated with mismatch repair deficiency in cancer Save
- Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial. Save
- Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways. Save
- Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations. Save
- Pan-cancer atlas of somatic core and linker histone mutations. Save
- Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003. Save
- Germline Elongator mutations in Sonic Hedgehog medulloblastoma. Save
- Pan-cancer analysis of whole genomes. Save
- Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma. Save
- Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort. Save
- The whole-genome panorama of cancer drivers Save
- Population Variation and Genetic Control of Modular Chromatin Architecture in Humans. Save
- Rounding Up Natural Gene Expression Variation during Development Save
- Identification and removal of low-complexity sites in allele-specific analysis of ChIP-seq data. Save
- Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription. Save
- Genomic variation and its impact on gene expression in Drosophila melanogaster. Save
- Integrative genomics identifies the corepressor SMRT as a gatekeeper of adipogenesis through the transcription factors C/EBPβ and KAISO. Save
- Systematic inference of copy-number genotypes from personal genome sequencing data reveals extensive olfactory receptor gene content diversity. Save