Shen Gu

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Publications (59)

• PRC2‐Related Epigenetic Age Acceleration in Acute Myeloid Leukemia with DNMT3A and IDH2 Mutations
  Advanced Biology 2026 DOI: 10.1002/adbi.202500710
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• Developmental chronology of mouse embryo from 2-cell stage through birth
  Nature Cell Biology 2026 DOI: 10.1038/S41556-026-01971-3
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• Epigenome editing based treatment: Progresses and challenges
  Molecular Therapy 2026 DOI: 10.1016/J.YMTHE.2025.08.047
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• The indispensable role of Mediator complex subunit 27 during neurodevelopment
  Cell & Bioscience 2025 DOI: 10.1186/s13578-025-01425-7
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• RNA Mis-Splicing Effects of Noncanonical Splicing Variants in Limb-Girdle Muscular Dystrophy Type R1/2A
  Neurology Genetics 2025 DOI: 10.1212/NXG.0000000000200259
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• Amelioration of premature aging in Werner syndrome stem cells by targeting SHIP/AKT pathway
  Cell & Bioscience 2025 DOI: 10.1186/S13578-025-01355-4
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• Gene print-based cell subtypes annotation of human disease across heterogeneous datasets with gPRINT
  Ruojin Yan, Chunmei Fan, Shen Gu +3 more
  Protein & Cell 2025 DOI: 10.1093/PROCEL/PWAF001
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• Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy
  Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo +16 more
  Advanced Science 2025 DOI: 10.1002/ADVS.202505535
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• A robust pipeline for ranking carrier frequencies of autosomal recessive and X-linked Mendelian disorders
  European Journal of Human Genetics 2024
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• Pathogenicity mechanism and gene therapy of hereditary spastic paraplegia caused by recurrent UBAP1 variant
  European Journal of Human Genetics 2024
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• Decoding hereditary spastic paraplegia pathogenicity through transcriptomic profiling
  Nicolas James Ho, Xiao Chen, Yong Lei +2 more
  Zoological Research 2023 DOI: 10.24272/J.ISSN.2095-8137.2022.281
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• Disease modeling of ADAMTS9-related nephropathy using kidney organoids reveals its roles in tubular cells and podocytes
  Frontiers in Medicine 2023 DOI: 10.3389/FMED.2023.1089159
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• Monoallelic variation in DHX9, the gene encoding the DExH-box helicase DHX9, underlies neurodevelopment disorders and Charcot-Marie-Tooth disease
  Daniel G. Calame, Tianyu Guo, Chen Wang +66 more
  The American Journal of Human Genetics 2023 DOI: 10.1016/J.AJHG.2023.06.013
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• Monoallelic variation in<italic> DHX9,</italic> the gene encoding the DExH-box helicase DHX9, underlies neurodevelopment disorders and Charcot-Marie-Tooth disease
  MedRxiv 2023 DOI: 10.1101/2023.03.01.23286475
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• Non-canonical C-terminal variant of MeCP2 R344W exhibits enhanced degradation rate
  IBRO Neuroscience Reports 2023 DOI: 10.1016/J.IBNEUR.2023.09.007
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• Single-cell analysis reveals specific neuronal transition during mouse corticogenesis
  Frontiers in Cell and Developmental Biology 2023 DOI: 10.3389/FCELL.2023.1209320
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• A Cd9+Cd271+ stem/progenitor population and the SHP2 pathway contribute to neonatal-to-adult switching that regulates tendon maturation
  Chunmei Fan, Yanyan Zhao, Yangwu Chen +12 more
  Cell Reports 2022 DOI: 10.1016/J.CELREP.2022.110762
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• A robust pipeline for ranking carrier frequencies of autosomal recessive and X-linked Mendelian disorders
  Wenjuan Zhu, Chen Wang, Nandita Mullapudi +7 more
  Npj Genomic Medicine 2022 DOI: 10.1038/S41525-022-00344-7
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• Developmental genomics of limb malformations: Allelic series in association with gene dosage effects contribute to the clinical variability
  Human Genetics and Genomics Advances 2022 DOI: 10.1016/J.XHGG.2022.100132
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• Functional characterization of Variants of Uncertain Significance (VUSs) identified in patients with early-life epilepsy in Hong Kong
  Genetics in Medicine 2022 DOI: 10.1016/J.GIM.2022.01.170
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