Dr. Madhav Nilakanth Mugale
Central Drug Research Institute, SA-FORD, Vivo Bio Tech Ltd
0000-0003-3138-3860
About
Having 12 years of experience in GLP, CIB, AAALACi and CIB certified discovery & contract research organization (CRO) private companies and Research labs. Having experience as study pathologist, study director, study personnel and study veterinarian in various studies regulatory studies. Mainly worked on various disease model development in laboratory animals. In discovery studies worked on diabetes and secondary complication, infectious disease, immunogenicity experiment, pharmacokinetics, Oncology model, Xenograft model development. In molecular pathology worked on immunohistochemistry, PCR, RT-PCR and ELISA. Having skills of laboratory animal experimentation and handling (including mice, rat, guinea pig, hamster, rabbit, monkey, dog, goat & large animals), dosing by various routes, blood collection, necropsy, histopathology, surgical model development. Worked in various in vivo regulatory toxicity studies in GLP and non GLP. It includes acute, subacute, chronic & carcinogenicity studies in various animals by various dose routes. Faced the various national and international audits as an animal house in charge (worked with rabbit facility and faced the audit of AAALACi accreditation). Having experience in SOP preparation, laboratory animal’s health monitoring. Having clinical practice experience in veterinary hospital.
Employment
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Central Drug Research Institute Senior Scientist2017 - Present
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SA-FORD Veterinary Pathology2017 - 2017
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Vivo Bio Tech Ltd Research scientist2015 - 2017
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Venus Remedies (India) Research scientist2011 - 2012
Education
Education history is unavailable.
Projects & Funding
Projects & funding information is unavailable.
Publications (28)
- Testosterone propionate maintains autophagic flux and mitochondrial integrity via regulation of the LC3B/p62/Beclin-1/mTOR axis in induced liver fibrosis Save
- A new sesquiterpene lactone isolated from Ainsliaea smithii and cytotoxic activity against the A549 cancer cell line Save
- Autophagy, Apoptosis, and Inflammatory Mechanisms in Chronic Respiratory Diseases: Interplay in Special Reference to Mitochondrial‐ER Stress Axis Save
- Evaluating the implications of K-Ras, KEAP1/NRF2-mediated signaling pathways and metabolic alterations in urethane-induced lung cancer Save
- Mitochondrial Metabolic Reprogramming along with NRF2/KEAP1-Mediated Antioxidant Mechanisms Drive Temozolomide Resistance in Glioblastoma Multiforme Save
- EZH2-mediated hypermethylation of H3K27me3 downregulates claudin-4 and upregulates the Wnt/β-catenin signaling pathway in hepatocellular carcinoma metastasis Save
- In vitro and in vivo studies: Fibro-hepatoprotective role of testosterone through modulation of Nrf2/PINK1-Drp1 axis in SD rats Save
- Metabolomics fingerprinting identifies redox-dependent inhibition of TXNIP alleviates renal fibrosis via modulation of TGF-β1/COL-1/ GRP78 signaling axis in a diabetic nephropathy rat model Save
- Untargeted metabolomics reveals Syzygium cumini (L.) alleviates ER stress and redox damage via activation of ATF-6/CHOP/NF-κB signaling axis in diabetic rats Save
- CYP2E1 overexpression in hepatocellular carcinoma modulates tumor invasion and migration via Wnt/β-catenin signaling pathway Save