NS
Ng Shyh-Chang
Institute of Zoology, CAS, Genome Institute of Singapore, A*STAR, Harvard Medical School, Princeton University
0000-0003-3138-9525
About
At the IOZ CAS, and previously at GIS A*STAR, my vision is to use the latest technologies in metabolomics, genomics, and 3D organoid cultures, to understand how we can modulate metabolic networks to control stem cell self-renewal, differentiation, and aging. This will have important implications for treating degenerative diseases such as pre-eclampsia, type 2 diabetes, sarcopenic obesity, and cancer cachexia.
Employment
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Institute of Zoology, CAS Professor, PI2017 - Present
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Genome Institute of Singapore, A*STAR GIS Fellow / Junior Group Leader2013 - 2017
Education
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Harvard Medical School PhD2009 - 2013
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Princeton University A.B. summa cum laude2005 - 2008
Projects & Funding
Projects & funding information is unavailable.
Publications (57)
- Metabolic control of feto–placental development and pregnancy outcomes Save
- Contractile myografts confer systemic anti-aging benefits Save
- Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses Save
- An obesogenic FTO allele causes accelerated development, growth and insulin resistance in human skeletal muscle cells. Save
- Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR Save
- Lin28a forms an RNA‐binding complex with Igf2bp3 to regulate m6A‐modified stress response genes in stress granules of muscle stem cells Save
- Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells. Save
- A multi-tissue metabolome atlas of primate pregnancy. Save
- Muscle injuries induce a prostacyclin‐PPARγ/PGC1a‐FAO spike that boosts regeneration Save
- XAI-enabled neural network analysis of metabolite spatial distributions Save