Carolyn Shembrey

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Publications (18)

• CRISPR in clinical oncology: translational advances from molecular diagnostics to therapeutics
  Nature Reviews Clinical Oncology 2026 DOI: 10.1038/s41571-026-01179-2
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• Target RNA abundance controls the collateral activity of RfxCas13d in human cells and zebrafish embryos
  2026 DOI: 10.21203/rs.3.rs-10351181/v1
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• Phase-Separated RNA Condensates Govern Cas13 Target Accessibility and Cleavage
  2026 DOI: 10.64898/2026.05.12.724747
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• Principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision
  Carolyn Shembrey, Ray Yang, Joshua M. L. Casan +10 more
  Science Advances 2024 DOI: 10.1126/sciadv.adl0731
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• Molecular principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision
  2023 DOI: 10.1101/2023.09.26.557083
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• A new natural killer cell-specific gene signature predicting recurrence in colorectal cancer patients
  Frontiers in Immunology 2023 DOI: 10.3389/fimmu.2022.1011247
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• A new highly-specific Natural Killer cell-specific gene signature predicting recurrence in colorectal cancer patients
  2022 DOI: 10.1101/2022.04.29.489868
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• Longitudinal Monitoring of Intra-Tumoural Heterogeneity Using Optical Barcoding of Patient-Derived Colorectal Tumour Models
  Cancers 2022 DOI: 10.3390/cancers14030581
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• Phenotypic Consequences of SLC25A40-ABCB1 Fusions beyond Drug Resistance in High-Grade Serous Ovarian Cancer
  Cancers 2021 DOI: 10.3390/cancers13225644
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• Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD–Driven Acute Myeloid Leukemia
  Cancer Discovery 2021 DOI: 10.1158/2159-8290.CD-20-0738
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• Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal Cancer
  2021 DOI: 10.1101/2021.02.04.429849
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• Reprogramming of serine metabolism is an actionable vulnerability inFLT3-ITDdriven acute myeloid leukaemia
  2020 DOI: 10.1101/2020.05.26.116392
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• Laminin 521 enhances self-renewal via STAT3 activation and promotes tumor progression in colorectal cancer.
  Cancer letters 2020 DOI: 10.1016/j.canlet.2020.02.026
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• Impact of Tumor and Immunological Heterogeneity on the Anti-Cancer Immune Response
  Cancers 2019 DOI: 10.3390/cancers11091217
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• Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells.
  Cancer research 2018 DOI: 10.1158/0008-5472.can-17-1869
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• Surgical stress response and promotion of metastasis in colorectal cancer: a complex and heterogeneous process.
  Clinical & experimental metastasis 2018 DOI: 10.1007/s10585-018-9873-2
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• 3002 – REPROGRAMMING OF SERINE METABOLISM IS A METABOLIC VULNERABILITY IN FMS-LIKE TYROSINE KINASE 3 (FLT3) MUTANT ACUTE MYELOID LEUKAEMIA
  Experimental Hematology DOI: 10.1016/j.exphem.2020.09.024
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• NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation
  Frontiers in Immunology DOI: 10.3389/fimmu.2022.931630
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