WAN FU

Employment

• The University of Texas Southwestern Medical Center postdoc
  2018 - 2019
• Shanghai Jiao Tong University associate researcher
  2017 - Present

Education

• Peking University phd
  2012 - 2017

Projects & Funding

Projects & funding information is unavailable.

Publications (14)

• Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload
  Nature Communications 2026 DOI: 10.1038/s41467-026-74814-2
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• CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis
  Advanced Science 2026 DOI: 10.1002/advs.202502239
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• Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload
  Biorxiv 2026 DOI: 10.64898/2026.01.28.702369
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• Sodium disrupts mitochondrial energy metabolism to execute NECSO
  Nature Communications 2025 DOI: 10.1038/s41467-025-67181-x
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• Persistent activation of TRPM4 triggers necrotic cell death characterized by sodium overload
  Wan Fu, Jianghuang Wang, Tianyu Li +15 more
  Nature Chemical Biology 2025 DOI: 10.1038/s41589-025-01841-3
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• RIPK4-mediated MFN2 degradation drives osteogenesis through mitochondrial fragmentation and restricts myelopoiesis by blocking mitochondrial transfer
  Nature Communications 2025 DOI: 10.1038/s41467-025-61808-9
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• RIPK4 promotes oxidative stress and ferroptotic death through the downregulation of ACSM1
  Proceedings of the National Academy of Sciences of the United States of America 2024 DOI: 10.1073/pnas.2410628121
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• C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy
  Nature Communications 2023 DOI: 10.1038/s41467-023-42003-0
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• WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2.
  Diabetes 2020 DOI: 10.2337/db19-0699
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• A novel acridine derivative, LS-1-10 inhibits autophagic degradation and triggers apoptosis in colon cancer cells.
  Cell death & disease 2017 DOI: 10.1038/cddis.2017.498
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• PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment
  Autophagy 2017 DOI: 10.1080/15548627.2016.1272742
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• Serine/hreonine Kinase Unc-51-like Kinase-1 (Ulk1)phosphorylates the co-chaperone cell division cycle protein 37 (Cdc37) and thereby disrupts the stability of Cdc37 client proteins
  Journal of Biological Chemistry 2017 DOI: 10.1074/jbc.M116.762443
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• Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62
  Molecular Cell 2016 DOI: 10.1016/j.molcel.2016.05.027
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• XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells
  Cell Research 2013 DOI: 10.1038/cr.2013.2
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