DO
David O'Connor
Great Ormond Street Hospital for Children NHS Foundation Trust, University College London, Imperial College London, University of Birmingham
Research areas: Medicine · Hematology · Acute Lymphoblastic Leukemia research · CAR-T cell therapy research · Acute Myeloid Leukemia Research
0000-0003-3542-5976
Employment
- 2024 - Present
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University College London Honorary Associate Professor2024 - Present
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Great Ormond Street Hospital for Children NHS Foundation Trust Honorary consultant2018 - 2024
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University College London Senior Clinical Fellow2018 - 2024
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Great Ormond Street Hospital For Children NHS Foundation Trust Locum Consultant2016 - 2018
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Imperial College London Clinical Research Fellow2011 - 2014
Education
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Imperial College London PhD Molecular Haematology2011 - 2014
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University of Birmingham MBChB1998 - 2004
Projects & Funding
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Leveraging MYB-dependencies for novel therapy of paediatric KMT2A-rearranged Acute Myeloid Leukaemia Little Princess Trust2026 - 2026
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Hem-iSmart international early phase trial Cancer Research UK2024 - 2029
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ALLTogether team science – development of a preclinical testing platform to improve outcomes for drug resistant T-cell Acute Lymphoblastic Leukemia Fight Kids Cancer2023 - 2027
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RElapse-specific therapeutic Vulnerability Evaluation in childhood & young adult ALL (REVEALL) Cancer Research UK2021 - 2024
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Deciphering the geNOmic landscape of childhood refractory T-cell Acute Lymphoblastic Leukaemia Children's Cancer and Leukaemia Group2021 - 2022
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Identifying drivers of central nervous system involvement in T-cell acute lymphoblastic leukaemia Children's Cancer and Leukaemia Group2021 - 2023
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MYB-directed Therapy for Paediatric Acute Myeloid Leukaemia Children with Cancer UK2021 - 2024
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Identifying the genetic and functional drivers of chemoresistant T-cell acute lymphoblastic leukaemia Cancer Research UK2018 - 2023
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Identifying the genetic and functional drivers of chemoresistant T-cell acute lymphoblastic leukaemia Cancer Research UK2018 - 2024
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The role of the fetal microenvironment in abnormal fetal haematopoiesis in Down Syndrome Kay Kendall Leukaemia Fund2011 - 2014
Publications (60)
- Reduced-intensity reinduction for children and young persons with relapsed acute lymphoblastic leukemia Save
- Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia Save
- Preclinical development of anti-CD21 chimeric antigen receptor T cells to treat T cell acute lymphoblastic leukemia Save
- British Society for Haematology updated guidelines for the diagnosis and management of tumour lysis syndrome in adults and children with haematological malignancies: A focus on patient safety Save
- Clinical Experience of Upfront Blinatumomab in Middle Eastern Patients With B-All at Great Ormond Street Hospital, London Save
- Late Onset Blinatumomab-Related Neurotoxicity in a Child With B-Cell Acute Lymphoblastic Leukemia Save
- Therapeutic Response to Imatinib in Bilateral Infiltrative and Leukostatic Retinopathy in Chronic Myelogenous Leukaemia Save
- Transcription factor cooperativity at a GATA3 tandem DNA sequence determines oncogenic enhancer-mediated activation Save
- Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia Save
- Update on long-term outcomes of a cohort of patients with TCF3::HLF-positive acute lymphoblastic leukemia treated with blinatumomab and stem cell transplantation Save
- Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia Save
- A Non-Canonical Lymphoblast in Refractory Childhood T-Cell Acute Lymphoblastic Leukemia Save
- Benefits for children with suspected cancer from routine whole-genome sequencing Save
- Blinatumomab for First-Line Treatment of Children and Young Persons With B-ALL Save
- Blinatumomab for First-Line Treatment of Children and Young Persons With B-ALL ( vol 42, pg 907, 2023) Save
- Noncoding mutations drive persistence of a founder preleukemic clone which initiates late relapse in T-ALL Save
- Real-world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies Save
- Single cell transcriptomics reveals a non-canonical lymphoblast in refractory childhood T cell leukaemia Save
- Stratified Medicine Paediatrics2-advancing precision medicine in paediatric cancer Save
- Cranial radiotherapy has minimal benefit in children with central nervous system involvement in T-ALL Save