Partha Pratim Das

About

Partha Das is a Principal Investigator and Head of the Gene Regulation Laboratory at the Monash Biomedicine Discovery Institute (BDI), Monash University, where he started his lab in 2017. Dr Das received his Master's in Molecular Biology from International Max Planck Research School (IMPRS), Gottingen, Germany. Then, he moved to the Gurdon Institute, University of Cambridge, UK, to do his PhD with Prof Eric Miska to study – the role of small RNAs/piRNAs in C.elegans germline development. For postdoctoral studies, he trained with Prof Stuart Orkin, an HHMI, at the Boston Children's Hospital/ DFCI, Harvard Medical School to study – how epigenetic changes regulate transcriptional gene regulation in embryonic stem cells (ESCs). Dr Das's research team is currently investigating how epigenetic and epitranscriptomic changes control gene regulation in embryonic stem cells (ESCs) and differentiated cells under normal and pathological conditions. He was the recipient of the London Law trust fellowship (2016), Cancer Research UK fellowship (2005-2009), and Max Planck Research Fellowship (2003-2005). Dr Das is also an Associate Investigator of Stem Cells Australia and a consultant for Algen Biotechnologies Inc., a biotech start-up based in SF, USA.

Employment

• Amaroq Therapeutics Chief Scientific Officer (CSO)
  2025 - Present
• Monash University Group Leader/Principal Investigator (Adjunct)
  2022 - Present
• Flagship Pioneering Associate Director, Venture Creation (Life Sciences)
  2022 - 2025
• Monash University Group Leader/Principal Investigator
  2017 - 2022
• Boston Children’s Hospital / Dana-Farber Cancer Institute, Harvard Medical School Post-Doctoral Fellow
  2010 - 2016

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (28)

• A basic framework to explain splice-site choice in eukaryotes
  Nature Communications 2025 DOI: 10.1038/s41467-025-63622-9
  +Save
• Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates
  Nature Structural & Molecular Biology 2025 DOI: 10.1038/s41594-024-01457-6
  +Save
• JMJD2 regulates enhancer–promoter interactions via biomolecular condensate formation
  Nature Genetics 2025 DOI: 10.1038/s41588-025-02415-8
  +Save
• The apparent loss of PRC2 chromatin occupancy as an artifact of RNA depletion
  Cell Reports 2024 DOI: 10.1016/j.celrep.2024.113858
  +Save
• MOV10 facilitates messenger RNA decay in an N6-methyladenosine (m6A) dependent manner to maintain the mouse embryonic stem cells state
  2021 DOI: 10.1101/2021.08.11.456030
  +Save
• Histone demethylome map reveals combinatorial gene regulatory functions in embryonic stem cells
  2021 DOI: 10.1101/2020.08.27.269514
  +Save
• Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas.
  Nature communications 2021 DOI: 10.1038/s41467-021-22543-z
  +Save
• TINC- A Method to Dissect Regulatory Complexes at Single-Locus Resolution- Reveals an Extensive Protein Complex at the Nanog Promoter.
  Stem cell reports 2020 DOI: 10.1016/j.stemcr.2020.11.005
  +Save
• A saturating mutagenesis CRISPR-Cas9-mediated functional genomic screen identifies -cis and trans- regulatory elements of Oct4 in murine ESCs.
  The Journal of biological chemistry 2020 DOI: 10.1074/jbc.ra120.013772
  +Save
• Reprogramming roadmap reveals route to human induced trophoblast stem cells.
  Nature 2020 DOI: 10.1038/s41586-020-2734-6
  +Save