SS
Sharad Kumar Suthar
Research areas: Chemistry · Organic Chemistry · Synthesis and biological activity · Natural product bioactivities and synthesis · Computational Drug Discovery Methods
0000-0003-3609-8057
Employment
Employment history is unavailable.
Education
Education history is unavailable.
Projects & Funding
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Development of the first non-muscle myosin-2 (NM2) specific inhibitor National Research, Development and Innovation Office (NKFIH), Hungary – ELTE's program of excellence to increase the capacity in synthetic chemistry and biochemistry: Synthesis+2020 - 2020
Publications (46)
- Discovery of potent and selective TRIB2 inhibitors with therapeutic efficacy in therapy-resistant neuroendocrine prostate cancer Save
- Fragment-based structure-activity relationship analysis of CK-571 reveals non-interacting groups drive smooth muscle myosin selectivity Save
- TRIB2 as a therapeutic vulnerability in ALK-rearranged non-small cell lung cancer Save
- TRIB2 regulates immune evasion in antiandrogen-resistant and neuroendocrine prostate cancer Save
- Synthesis, biological evaluation, and in silico studies of lantadene-derived pentacyclic triterpenoids as anticancer agents targeting IKK-β Save
- Behavior Reprogramming by Single-Neuron Molecular Tattooing of Native NMDA Receptors Save
- Comprehensive SAR analysis of actomyolytics, drug candidates targeting the actomyosin complex Save
- Truncation or proteolysis of α-synuclein in Parkinsonism Save
- The Role of Superoxide Dismutase 1 in Amyotrophic Lateral Sclerosis: Identification of Signaling Pathways, Regulators, Molecular Interaction Networks, and Biological Functions through Bioinformatics Save
- Ingenuity pathway analysis of α-synuclein predicts potential signaling pathways, network molecules, biological functions, and its role in neurological diseases Save
- (+)-Cyanidan-3-ol inhibits epidermoid squamous cell carcinoma growth via inhibiting AKT/mTOR signaling through modulating CIP2A-PP2A axis Save
- First-in-class drug candidate (MPH-220) efficiently improves spastic gait disorders by selective inhibition of fast skeletal muscle myosin-2 Save
- Chiral HPLC separation of enantiomeric blebbistatin derivatives and racemization analysis in vertebrate tissues Save
- Bioinformatic Analyses of Canonical Pathways of TSPOAP1 and its Roles in Human Diseases Save
- Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) Properties of Blebbistatin Derivatives Indicate That Blebbistatin Scaffold Is Ideal for drug Development Targeting Myosin-2 Save
- Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness Save
- Isolation optimisation, synthesis, molecular docking and in silico ADMET studies of lantadene a and its derivatives Save
- SAR Analysis of Linker Derivatives of the Smooth Muscle Myosin Specific CK-571 Compound Save
- The New-Generation Muscle Relaxant MPH-220 Dissolves Spasticity in Muscles After Cns Injury - a Promising Drug to Address Post-Stroke Spasticity Save
- Pharmaceutically effective compounds inhibiting selectively the myosin 2 isoforms Save