Krishna Chinthalapudi

Employment

Employment history is unavailable.

Education

Education history is unavailable.

Projects & Funding

• Molecular Basis for cMyBP-C HCM variants National Heart Lung and Blood Institute
  2025 - 2029
• Biological basis of cardiac thick filament regulation National Heart Lung and Blood Institute
  2025 - 2029
• Structure and function of nonmuscle myosins National Institute of General Medical Sciences
  2021 - 2026
• Lipid-Directed Control of Merlin Tumor Suppressor Functions Children's Tumor Foundation
  2014 - 2016

Publications (30)

• Structural basis of nonmuscle myosin-2 autoinhibition mechanisms
  Nature Communications 2026 DOI: 10.1038/s41467-026-74674-w
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• Structural and functional mechanisms underlying activation gate dynamics and IFM motif accessibility in human Nav1.5
  Rupam Biswas, Ana Laura López-Serrano, Apoorva Purohit

  +6 more

  • Angelina Ramirez‐Navarro
  • Hsiang-Ling Huang
  • Xiaolin Cheng
  • Sarah M. Heissler
  • Isabelle Deschênes
  • +1 more
  Nature Communications 2026 DOI: 10.1038/s41467-026-69672-x
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• Actin arginylation alters myosin engagement and F-actin patterning despite structural conservation
  Journal of Cell Biology 2026 DOI: 10.1083/jcb.202409067
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• Molecular Control of Non-Muscle Myosin II-A Aggregation and Intracellular Dynamics by motor- or tail-specific MYH9 Mutations
  2025 DOI: 10.1101/2025.05.20.654665
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• Structural basis of human Na v 1.5 gating mechanisms
  Rupam Biswas, Ana Laura López-Serrano, Apoorva Purohit

  +7 more

  • Angelina Ramirez‐Navarro
  • Hsiang-Ling Huang
  • Giovanna Grandinetti
  • Xiaolin Cheng
  • Sarah M. Heissler
  • +2 more
  Proceedings of the National Academy of Sciences 2025 DOI: 10.1073/pnas.2416181122
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• Structural and functional mechanisms of actin isoforms
  The FEBS Journal 2025 DOI: 10.1111/febs.17153
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• Structure, regulation, and mechanisms of nonmuscle myosin-2
  Cellular and Molecular Life Sciences 2024 DOI: 10.1007/s00018-024-05264-6
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• Cryo-EM structures of the membrane repair protein dysferlin
  Nature Communications 2024 DOI: 10.1038/s41467-024-53773-6
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• Structural insights into actin isoforms
  eLife 2023 DOI: 10.7554/eLife.82015
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• Competition between myosin II and βH-Spectrin regulates cytoskeletal tension
  2022 DOI: 10.1101/2022.12.01.518662
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• Structural Mechanisms of Actin Isoforms
  2022 DOI: 10.1101/2022.08.01.502282
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• Cryo-EM structure of the autoinhibited state of myosin-2
  Science Advances 2021 DOI: 10.1126/sciadv.abk3273
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• A distinct talin2 structure directs isoform specificity in cell adhesion
  Journal of Biological Chemistry 2020 DOI: 10.1074/jbc.RA119.010789
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• The BAR domain of the Arf GTPase-activating protein ASAP1 directly binds actin filaments
  Journal of Biological Chemistry 2020 DOI: 10.1074/jbc.RA119.009903
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• Kinetic signatures of myosin-5B, the motor involved in microvillus inclusion disease
  Journal of Biological Chemistry 2017 DOI: 10.1074/jbc.M117.801456
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• Mechanistic Insights into the Active Site and Allosteric Communication Pathways in Human Nonmuscle Myosin-2C
  eLife 2017 DOI: 10.7554/elife.32742
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• Human metavinculin (residues 959-1134) in complex with PIP2
  2016 DOI: 10.2210/pdb5l0c/pdb
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• Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization
  Proceedings of the National Academy of Sciences of the United States of America 2016 DOI: 10.1073/pnas.1600702113
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• Kinetic characterization of the sole nonmuscle myosin-2 from the model organism Drosophila melanogaster
  FASEB Journal 2015 DOI: 10.1096/fj.14-266742
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• Lipid-directed vinculin dimerization
  Krishna Chinthalapudi, Dipak N. Patil, Erumbi S. Rangarajan

  +2 more

  • Christoph M. Rader
  • Tina Izard
  Biochemistry 2015 DOI: 10.1021/acs.biochem.5b00015
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