Kohei Kumegawa
Japanese Foundation For Cancer Research, Tohoku University, Sapporo Medical University
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Epigenetics and DNA Methylation · Cancer Cells and Metastasis · Genomics and Chromatin Dynamics
0000-0003-3732-2874
About
A data scientist and strategist (MD, PhD) specializing in single-cell and multi-omics analyses; I am engaged in translational research at Japan’s leading cancer center. Guided by the mission of “driving the next discovery”, my work transcends cancer types and integrates collaborations with clinicians, pathologists, and basic scientists. Through comprehensive data-driven approaches, I aim to uncover novel insights into tumor biology and accelerate advances that bridge fundamental science with clinical applications.
Employment
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Japanese Foundation For Cancer Research Clinical Research Fellow2020 - Present
Education
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Tohoku University Doctor of Philosophy in Medicine (Ph.D.)2020 - 2023
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Sapporo Medical University Doctor of Medicine (M.D.)2010 - 2016
Projects & Funding
Projects & funding information is unavailable.
Publications (36)
- Clonal lineage tracing and parallel multiomics profiling reveal transcriptional heterogeneity induced by ARID1A deficiency Save
- Plasticity of extrachromosomal DNA segregation during drug adaptation Save
- Colorectal cancer co-opts an epidermal wound healing program during metastasis to generate disseminated tumor cells Save
- Long-term intermittent estradiol exposure induces epithelial–mesenchymal transition-like plasticity in MCF10A cells Save
- Transgelin defines pro-tumorigenic cancer-associated fibroblasts in pancreatic cancer Save
- Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma Save
- Ribosome biogenesis as a potential therapeutic target in KRAS mutant colorectal cancer Save
- Synthetic lethality from the combination of a histone methyltransferase SUV39H2 inhibitor and a poly (ADP-ribose) polymerase inhibitor for uterine leiomyosarcoma Save
- Plasticity of extrachromosomal DNA segregation during drug adaptation Save
- Characterizing heterogeneous cis-regulatory elements in gene regulatory programs associated with breast cancer Save
- DOT1L inhibition exerts the anti-tumor effect by activating interferon signaling in breast cancer cells Save
- DOT1L inhibition reprograms innate immunity to potentiate immunomodulatory drug responses in multiple myeloma Save
- Breast cancer identity is defined by specialized enhancer sets via lysine deacetylation Save
- Axillary adipose tissue–derived lymphatic endothelial cells exhibit distinct transcriptomic signatures reflecting lymphatic invasion status in breast cancer Save
- Clonal lineage tracing and parallel multiomics profiling reveal transcriptional diversification induced by ARID1A deficiency Save
- Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression Save
- Human TIMELESS, a potential circadian clock regulator, plays an essential role in survival and reawakening of metastasis-initiating cells in bone Save
- Single-cell RNA-seq analysis of cancer-endothelial cell interactions in primary tumor and peritoneal metastasis from a single patient with colorectal cancer Save
- Serial single-cell RNA sequencing unveils drug resistance and metastatic traits in stage IV breast cancer Save
- Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression Save