RAJKUMAR KULANDAISAMY
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · RNA and protein synthesis mechanisms · Protein Structure and Dynamics · SARS-CoV-2 and COVID-19 Research
0000-0003-3789-5891
About
Dr. Rajkumar Kulandaisamy is a Postdoctoral Associate in the laboratory of Joan A. Steitz in the Department of Molecular Biophysics and Biochemistry at Yale School of Medicine. His research focuses on RNA biology and virus–host interactions, with particular interest in the highly abundant Kaposi’s sarcoma–associated herpesvirus (KSHV) long noncoding PAN RNA and its role in regulating viral gene expression and nuclear mRNA export during lytic infection. Using molecular biology, biochemical, and structural approaches, his work aims to uncover how viral noncoding RNAs manipulate host cellular machinery to promote infection and gene expression.
Dr. Kulandaisamy earned his PhD in Biophysics from the All India Institute of Medical Sciences (AIIMS), New Delhi, where he investigated the catalytic mechanism of peptidyl-tRNA hydrolase from Mycobacterium tuberculosis and explored potential therapeutic targets for tuberculosis. He previously completed his B.Sc. and M.Sc. in Microbiology at Bharathidasan University. His research broadly aims to uncover fundamental mechanisms of RNA-mediated regulation in both viral and cellular systems.
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Publications (13)
- Structural and dynamic basis of tRNA recognition by Mycobacterium tuberculosis peptidyl-tRNA hydrolase Save
- In Silico Screening and Molecular Dynamics Simulations of Small Molecules Targeting Peptidyl tRNA Hydrolase for Drug-Resistant Tuberculosis Save
- Mycobacterium tuberculosis virulence-associated small RNA MTS1338 is posttranscriptionally regulated by the ribonuclease YbeY Save
- Ethyl acetate extract of Ruta graveolens: a specific and potent inhibitor against the drug-resistant EGFR_T790M mutant in NSCLC Save
- Redefining NSP12 activity in SARS-CoV-2 and its regulation by NSP8 and NSP7 Save
- Interactions of SARS-CoV-2 nsp7 or nsp8 with nsp12 causes severe constriction of RNA entry channel: Implications for novel RdRp inhibitor drug discovery Save
- A comprehensive proteomic profiling of urinary exosomes and the identification of early non-invasive biomarker in patients with coronary artery disease Save
- Interactions of SARS-CoV-2 nsp7 or nsp8 with nsp12 causes severe constriction of RNA entry channel: Implications for novel RdRp inhibitor drug discovery Save
- Interaction of SCoV-2 NSP7 or NSP8 alone may cause constriction of the RNA entry channel in NSP12: Implications for novel RdRp inhibitor drug discovery Save
- New biochemical insights of CCA enzyme role in tRNA maturation and an efficient method to synthesize the 3'-amino-tailed tRNA Save
- Repurposing of FDA Approved Drugs Against SARS-CoV-2 Papain-Like Protease: Computational, Biochemical, and in vitro Studies Save
- Biochemical and Biophysical Characterisation of the Hepatitis E Virus Guanine-7-Methyltransferase Save
- Characterization of active/binding site residues of peptidyl-tRNA hydrolase using biophysical and computational studies Save