Mahima Sharma
University of York, University of York Department of Chemistry, University of Oxford, Department of Chemistry, University of Delhi
About
Mahima Sharma is a Research Fellow with expertise in structural enzymology and biocatalysis projects. She is currently working as a RCo-Investigator on BBSRC grant BB/W003805/01 on molecular dissection of sulfoglycolysis pathways with Professor Gideon Davies, FMedSci, FRS, at the York Structural Biology Laboratory.
Mahima is a 2021 RSC Horizon prize awardee for collaborative research with industrial partners, GSK, Prozomix, and Manchester Institute of Biotechnology and also won a recent 2024 RSC Horizon prize, for her work on breakdown pathways of ubiquitous plant sulfolipids, with researchers from University of Melbourne, Meiji University and Kyoto University.
Previously, she completed her DPhil in Chemical Biology from the University of Oxford in 2015 and worked on designing artificial metalloenzymes for C-C cross-coupling reactions under the supervision of Professor Benjamin G. Davis, FRS, and then began her postdoctoral work on structural and biochemical studies of enzymes enabling chiral amine synthesis (IREDs and reductive aminases) with Professor Gideon Grogan and Professor Nicholas J. Turner.
Employment
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University of York Research Fellow (RCo-Investigator, BBSRC grant BB/W003805)2022 - Present
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University of York Department of Chemistry Postdoctoral Research Associate (Davies Group)2018 - 2022
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University of York Department of Chemistry Postdoctoral Research Associate (Grogan Group)2015 - 2018
Education
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University of Oxford, Department of Chemistry DPhil in Chemical Biology2010 - 2014
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University of Delhi B.Sc. Chemistry (Hons)2007 - 2010
Projects & Funding
Projects & funding information is unavailable.
Publications (39)
- Structure of the imine reductase from Ajellomyces dermatitidis in three crystal forms. Corrigendum Save
- Metal‐Dependent 2‐Keto‐3,6‐dideoxy‐6‐sulfo‐gluconate (KDSG) Aldolase: Decoding the Key C─C Bond Cleaving Step in Bacterial Sulfoglycolysis Save
- Bridging a Gap in Marine Sulfur Cycling: Discovery of a d-Cysteinolic Acid Degradation Pathway Save
- Structures of “Tyrosine‐IRED” IR91 from Kribbella flavida in Complex with a Reductive Amination Substrate and Product Save
- Sulfoglycolysis sustains Eubacterium rectale in low-fiber diets Save
- Structure, kinetics, and mechanism of Pseudomonas putida sulfoquinovose dehydrogenase, the first enzyme in the sulfoglycolytic Entner-Doudoroff pathway Save
- Detection of Sulfoquinovosidase Activity in Cell Lysates Using Activity‐Based Probes Save
- Detection of Sulfoquinovosidase Activity in Cell Lysates Using Activity‐Based Probes Save
- Capture-and-release of a sulfoquinovose-binding protein on sulfoquinovose-modified agarose Save
- Widespread Family of NAD+-Dependent Sulfoquinovosidases at the Gateway to Sulfoquinovose Catabolism Save