RC
Rita Chen
National Taiwan University, Academia Sinica, University of Cambridge
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Alzheimer's disease research and treatments · Protein Structure and Dynamics · Prion Diseases and Protein Misfolding
0000-0003-3987-033X
Employment
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Academia Sinica Deputy Director2019 - 2022
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National Taiwan University Adjunct Professor2018 - Present
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Academia Sinica Research Fellow2017 - Present
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Academia Sinica Associate Research Fellow2010 - 2017
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Academia Sinica Assistant Research Fellow2003 - 2010
Education
- 1993 - 1998
Projects & Funding
Projects & funding information is unavailable.
Publications (44)
- Cryo‐EM Analysis of Bovine PrP(108–144) Fibrils and Implications for Sequence‐Dependent Species Barriers Save
- 2.2 Å Cryo-EM Tetra-Protofilament Structure of the Hamster Prion 108–144 Fibril Reveals an Ordered Water Channel in the Center Save
- Condition‐dependent structural collapse in the intrinsically disordered N‐terminal domain of prion protein Save
- Biodistribution analysis of an intranasal-delivered peptide by the nanoSPECT/CT imaging Save
- Location of the cross‐β structure in prion fibrils: A search by seeding and electron spin resonance spectroscopy Save
- Bio-Distribution Analysis of an Intranasal-Delivered Peptide by the Nanospect/Ct Imaging Save
- Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity Save
- A Systematic Study of the Stability, Safety, and Efficacy of the de novo Designed Antimicrobial Peptide PepD2 and Its Modified Derivatives Against Acinetobacter baumannii Save
- Self-Replication of Prion Protein Fragment 89-230 Amyloid Fibrils Accelerated by Prion Protein Fragment 107-143 Aggregates Save
- Segments in the Amyloid Core that Distinguish Hamster from Mouse Prion Fibrils Save
- An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice Save
- Amyloid Core Formed of Full-Length Recombinant Mouse Prion Protein Involves Sequence 127-143 but Not Sequence 107-126 Save
- How do amino acid substitutions affect the amyloidogenic properties and seeding efficiency of prion peptides Save
- Thioflavin T and Its Photoirradiative Derivatives: Exploring Their Spectroscopic Properties in the Absence and Presence of Amyloid Fibrils Save
- Curcumin's pre-incubation temperature affects its inhibitory potency toward amyloid fibrillation and fibril-induced cytotoxicity of lysozyme Save
- E3-independent ubiquitination of AtMAPR/MSBP1 Save
- Observation of protein folding/unfolding dynamics of ubiquitin trapped in agarose gel by single-molecule FRET Save
- Slow spontaneous alpha-to-beta structural conversion in a non-denaturing neutral condition reveals the intrinsically disordered property of the disulfide-reduced recombinant mouse prion protein Save
- Leu138 in bovine prion peptide fibrils is involved in seeding discrimination related to codon 129 M/V polymorphism in the prion peptide seeding experiment Save
- A highly sensitive peptide substrate for detecting two A beta-degrading enzymes: Neprilysin and insulin-degrading enzyme Save