0000-0003-4047-0560 About
My doctoral research focuses on uncovering how cells regulate the maintenance and timely disassembly of primary cilium (PC). My fascination with primary cilia began with their paradoxical nature, a single, tiny organelle that quietly governs how cells sense, communicate, and respond to their environment. Present on nearly all differentiated vertebrate cells, the PC functions as a sensory antenna, coordinating signaling pathways such as Sonic Hedgehog (SHH), Wnt and PDGF that are essential for development and tissue homeostasis. Yet, in cycling cells, its assembly and disassembly are delicately synchronized with the cell cycle, and minor disruptions in this balance can lead to tumorigenesis or various ciliopathies including several neurodegenerative disorders.
Employment
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Institute of Health Sciences, Presidency University Research Scholar2021 - 2026
Education
Education history is unavailable.
Projects & Funding
Projects & funding information is unavailable.
Publications (7)
- A brief exposure to rotenone alters microtubule dynamics resulting in aberrant elongation of primary cilia with impaired function Save
- Tubulin hyperacetylation drives HMGB1 nuclear exit via the ROS-PARP1 axis, leading to rotenone-induced G2/M arrest Save
- Tubulin hyperacetylation drives HMGB1 nuclear exit via the ROS-PARP1 axis leading to rotenone-induced G2/M Arrest Save
- Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis Save
- Increase in primary cilia number and length upon VDAC1 depletion contributes to attenuated proliferation of cancer cells Save
- Increase in primary cilia number and length upon VDAC1 depletion contributes to attenuated proliferation of cancer cells Save
- Freeing the brake: Proliferation needs primary cilium to disassemble Save