Michael L. Smith
Also known as: M. L. Smith, Mike Smith
IntechOpen, Many pharmaceutical/nutraceutical companies, Umeå University, Colorado State University, Arizona State University
Research areas: Biochemistry, Genetics and Molecular Biology · Biochemistry · Hemoglobin structure and function · Cosmology and Gravitation Theories · Metal-Catalyzed Oxygenation Mechanisms
0000-0003-4103-8614
About
Biophysics, biochemistry: spectroscopy; NMR, including paramagnetic (high- and low-spin Fe+3 hemes); infrared, including isotope shifts; UV-Vis; electron paramagnetic resonance (EPR) and 3D crystallography/structures of lactoperoxidase. Protein thermodynamics; protein-protein interactions with effects of single nucleotide polymorphisms (SNP), Hb S, Hb C, many more SNPs; kinetics and thermodynamics of protein stability/instability in non-denaturing conditions. Atomic oxygen (ATOX) biosynthesis.
Medicine: Developed a rapid, sensitive, specific D-dimer latex-agglutination test (deep vein thrombosis, lung embolism, COVID-19 pathologies). Developed a much more sensitive prothrombin time (PT coagulation) test.
Genetics: helped develop data reference libraries including human cancer genetics.
Fundamental physics: A more general version of the Einstein field equation.
Cosmology: examining supernovae (SNe Ia) and HII burst emission data. Currently interested in the real meanings of the values for the spacetime parameter, the \Omega_k, and the cosmological constant \Lambda, of the FLRW model. Applied math w/r to cosmology.
Never purchased a new or used Mercedes-Benz, Audi, BMW or Volkswagen (https://www.youtube.com/watch?v=k65Z-62hIr8). Never will. Parents met at Bletchley Park, 1941-45.
Employment
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IntechOpen Editor for "Cosmology Research - Addressing Current Problems with Astrophysics" (book)2024 - 2025
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Many pharmaceutical/nutraceutical companies Consultant, now retired1995 - 2018
Education
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Umeå Universitet M.D.Sc.1982 - 1984
- 1974 - 1979
- 1968 - 1972
Projects & Funding
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Biophysics of Sickle Cell Hemoglobin American Heart Association1980 - 1981
Publications (60)
- The mechanism of mammalian peroxidase destruction of invasive microbes Save
- The Beneficial High Iodine Diet: International Aspects Save
- Predicting the Future Using Pantheon+TRGB Data: Better Analytical Techniques with Friedmann-Lemaître-Robertson-Walker Models Save
- Energy calculations for atomic oxygen liberation from hypohalous acids biosynthesized by mammalian peroxidases Save
- Lactoperoxidase and Nutritional Iodine Prevent Serious Airborne Infections Save
- High dietary iodine intake may contribute to the low death rate from COVID‐19 infection in Japan with activation by the lactoperoxidase system Save
- Dark Matter - Recent Observations and Theoretical Advances Save
- Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase Save
- Dark Matter in Spiral Galaxies as the Gravitational Redshift of Gravitons Save
- Comments on the Discussion Forum: Oromucosal immunomodulation as clinical spectrum mitigating factor in SARS-CoV-2 infection Save
- Iodide supplementation of the anti-viral duox-lactoperoxidase activity may prevent some SARS-CoV-2 infections Save
- Re-evaluation of \Omega_k of the normalised Friedmann-Lemaître-Robertson-Walker model: Implications for Hubble constant determinations Save
- Försökte Umeå universitet övertala dr Charpentier att stanna? Save
- Tension over the Hubble-Lemaitre Constant (>950 downloads) Save
- The varying cosmological constant (>200 downloads, >1000 reads) Save
- A More General Einstein Field Equation with Predictions for Physics Save
- Einstein Field Equation; The More General Relationship Save
- Einstein Field Equations to Microscopic Gravity: Gravity, matter and spacetime for sub-atomic physics Save
- How distant can we see? Our optical horizon, R_h, redshift, spacetime "expansion" and curved spacetime Save
- Lawrence Krauss: Do your homework Save