Dr. Dablu Lal Gupta
All India Institute of Medical Sciences Raipur, All-India Institute of Medical Sciences, Nirma University
0000-0003-4394-5138
About
Research Interest: Analysis of innate and adaptive immune responses.
Summary of Research
The broad aim of research efforts in my laboratory is to track the generation and maintenance of immune responses following infection or cancer and to study the crosstalk between Myeloid Derived Suppressor Cells (MDSCs) and T Cells.
We have the following two major areas of interest:
1. Understanding the role of MDSCs in the development of the immunosuppressive networks in the cancer:
MDSCs are a heterogeneous population of cells that consists of myeloid progenitor cells and immature myeloid cells. In healthy individuals, MDSCs are generated in the bone marrow and quickly differentiate into mature granulocytes, DCs or macrophages. However, under pathological conditions (such as cancer), various infectious diseases and certain autoimmune diseases, a partial block in the MDSC differentiation into mature myeloid cells results in the expansion of this cell population. The ability of MDSCs to suppress antitumor Th1 cells and cytotoxic T-lymphocytes (CTL) immune responses have been demonstrated to impact the immune system directly and indirectly. The unique roles of MDSCs in the development of the immunosuppressive network indicate that this cell population may have potential as a therapeutic modality in cancer.
2. Identification of novel biomarkers of sepsis and septic shock in trauma patients
The primary focus of our research is to understand how Trauma haemorrhagic shock (THS) patients developed complications such as sepsis, septic shock and MOF in the ICU. We are mainly interested to know how changes in serum levels of biological markers such as cytokines, chemokines and C-reactive proteins correlate with severity of injury and outcomes. We are using the approach of molecular biology and immunology to understand the causes of mortality in THS patients.
Employment
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All India Institute of Medical Sciences Raipur Associate Professor2024 - Present
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All-India Institute of Medical Sciences Assistant Professor2020 - 2024
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Nirma University Assistant Professor2018 - 2020
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Jamia Millia Islamia National Post Doctorate Fellow2017 - 2018
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Translational Health Science and Technology Institute Research Associate2015 - 2017
Education
Education history is unavailable.
Projects & Funding
Projects & funding information is unavailable.
Publications (11)
- Analysis of the Total Immunoglobulin G (IgG) and Its Subclasses Over Time in Coronavirus Disease 2019-Recovered Patients and Its Association With Disease Severity: A Single-Center Prospective Cohort Study. Save
- Emerging severe acute respiratory syndrome coronavirus 2 variants and their impact on immune evasion and vaccine-induced immunity. Save
- Effect of Unmetabolized Folic Acid on Immunoinflammatory Markers in Sickle Cell Disease Patients Taking Folic Acid Supplementation. Save
- RBD mutations at the residues K417, E484, N501 reduced immunoreactivity with antisera from vaccinated and COVID-19 recovered patients. Save
- Understanding sepsis-induced immunosuppression and organ dysfunctions: from immunosuppression to immunotherapy Save
- Antibiotic-resistant bacteria originating from the gut may modulate the mucosal immune response during sepsis and septic shock. Save
- Estrogen as a Safe Therapeutic Adjunct in Reducing the Inflammatory Storm in Trauma Hemorrhagic Shock Patients. Save
- Changes in the behaviour of monocyte subsets in acute post-traumatic sepsis patients. Save
- Coexistence of Th1/Th2 and Th17/Treg imbalances in patients with post traumatic sepsis. Save
- Clinical relevance of single nucleotide polymorphisms within the 13 cytokine genes in North Indian trauma hemorrhagic shock patients. Save