Rajesh Kumar
Loyola University Maryland, Precise Bio Inc, National Dairy Research Institute, Panjab University, Precise Bio Inc.
0000-0003-4478-1518
About
My long term research goal is to investigate mechanisms of cardiac remodeling in diabetes and metabolic syndrome, and to identify viable targets for cardiac regeneration and prevention of cardiac arrhythmia. We have described a novel, intracellular component of the renin-angiotensin system (RAS), called intracrine RAS, in the heart and its significance in diabetic cardiomyopathy. Additionally, our new data has pointed towards the role of the intracellular RAS in the regulation of cardiac conductance, thus arrhythmias, through novel protein: protein interactions with XIRP1. Intracellular Ang II also modulates nuclear localization of proteins that control proliferation of cardiomyocytes. We are studying the regulation, role, and mechanism of the intracrine RAS in the heart using in vitro and in vivo approaches. We utilize knockout and transgenic mice in combination with pharmacological models of diabetes and metabolic syndrome. We perform in vitro cell signaling studies using neonatal and adult cardiomyocytes. We have expertise in echocardiography and catheter-based hemodynamic measurements to study heart function. Other approaches used in my laboratory include mass spectrometry, real-time RT-PCR, Western analysis, histology, and confocal microscopy.
Employment
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Loyola University Maryland Director2022 - Present
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Precise Bio Inc Scientific Director2020 - 2022
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Precise Bio Inc. Scientific Manager2018 - 2020
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Texas A&M University Health Sciences Center Adjunct Associate Professor2017 - 2022
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Texas A&M University Health Sciences Center Research Associate Professor2015 - 2017
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Texas A&M University Health Sciences Center Associate Professor2010 - 2015
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Texas A&M University Health Sciences Center Assistant Professor2003 - 2010
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Texas A&M University Health Science Center Research Associate2000 - 2002
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University of Virginia Research Associate1996 - 2000
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Institute of Microbial Technology CSIR Research Associate? - 1996
Education
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National Dairy Research Institute M.Sc.1985 - 1987
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Panjab University Ph.D.? - 1994
Projects & Funding
Projects & funding information is unavailable.
Publications (52)
- Phosphorylation of Cardiac Myosin Binding Protein-C is a Critical Mediator of Diastolic Function Save
- Activation of Foxo1 by insulin resistance promotes cardiac dysfunction and $β$--myosin heavy chain gene expression Save
- Hydrogen sulfide inhibits activation of the renin-angiotensin system in diabetic heart Save
- Novel Mechanism of Blood Pressure Regulation By Forkhead Box Class O1--Mediated Transcriptional Control of Hepatic Angiotensinogen Save
- Cardiac-specific suppression of NF-$κ$B signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system Save
- Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors Save
- Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor Save
- Do Multiple Nuclear Factor Kappa B Activation Mechanisms Explain Its Varied Effects in the Heart? Save
- Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38 alpha MAPK During Insulin Resistance Save
- Cardiac-specific genetic inhibition of nuclear factor-kappa B prevents right ventricular hypertrophy induced by monocrotaline Save