William L Hwang

About

I am a Principal Investigator and Physician-Scientist at the Center for Systems Biology, Center for Cancer Research, and Department of Radiation Oncology at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) where I lead the Laboratory for Spatial and Systems Oncology and care for patients with pancreatic cancer and other gastrointestinal malignancies. I also serve as the Associate Director of the Radiation Biology & Research Program at the MGH Cancer Center and teach graduate school courses on the faculty of the Harvard Biological and Biomedical Sciences (BBS) Program and Harvard-MIT Health Science and Technology Program. I am an Associate Member of the Broad Institute of MIT and Harvard. I have a long-standing interest in the immense temporal and spatial heterogeneity of biological systems and the many insights that can only be gleaned by studying systems at the level of their individual components—single molecules or cells. My laboratory is focused on studying tumor-stroma interactions in cancer at unprecedented resolution through the development and application of techniques in advanced microscopy, single-cell and spatial biology, and genetic engineering to patient-derived specimens, stromal tumoroids, and mouse models. I am particularly interested in elucidating the (1) mechanisms of therapeutic resistance mediated by cancer cell-stromal interactions in the tumor microenvironment; (2) cell state plasticity involved in tumorigenesis and therapeutic resistance; and (3) mechanisms of tumor-nerve interactions, which are remarkably important in the pathogenesis of many cancers but poorly understood. Please visit my lab website at whwanglab.org for more information. My research has resulted in more than 40 peer-reviewed publications in high-impact journals including Nature, Cell, Nature Genetics, Nature Nanotechnology, Lancet Oncology and JAMA Oncology; numerous competitive research grants at the national level; two patents (63/069,035, 63/346,670); and several awards including the Martha Gray Prize for Excellence in Research, Seidman Prize for Outstanding Thesis, summa cum laude graduation honors from Harvard Medical School, MGH Clinical Research Award, William Shipley Research Award, ASCO/CCF Young Investigator Award, MIT Koch Institute Image Award, AACR NextGen Star, Burroughs Wellcome Fund Career Award for Medical Scientists, Pancreatic Cancer Action Network Career Development Award, and 40 under 40 in Cancer – Rising Stars and Emerging Leaders.

Employment

• Massachusetts General Hospital Principal Investigator
  2022 - Present
• Harvard Medical School Assistant Professor

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications

Publications are unavailable.