Akhilesh Kotiyal
Research areas: Medicine · Physiology · Pain Mechanisms and Treatments · Ion Channels and Receptors · Cancer Treatment and Pharmacology
0000-0003-4726-4997
About
I am a Postdoctoral Research Associate in the Department of Anesthesiology at Washington University in St. Louis, USA. I received my Ph.D. from Indian Institute of Technology (Banaras Hindu University), Varanasi, India.
My research focuses on neuroscience, pharmacology, and pain biology. During my Ph.D., I studied the role of ion channels in neuropathic pain and chemotherapy-induced peripheral neuropathy. My current research investigates the biological mechanisms underlying migraine, chronic pain, and neuroimmune interactions.
I use preclinical models and molecular approaches to understand how changes in the nervous and immune systems contribute to pain sensitization and disease progression. My research interests include migraine, neuroimmune signaling, ion channels, and the development of new therapeutic strategies for neurological and pain disorders.
My long-term goal is to translate basic science discoveries into better treatments that improve patient outcomes.
Employment
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Publications (48)
- Design, synthesis, and in vitro evaluation of novel 2-(5,8-dimethyl-2-naphthyl) propanoic acid derivatives as selective COX-2 inhibitors Save
- Role of microglia in neurodegenerative disorders Save
- Investigating the Role of Complement C5aR1 Signaling in Chronic Migraine Save
- Development of Transient Receptor Potential Ankyrin-1 (TRPA1) Nociceptor-Based siRNA Nanotherapeutics for the Treatment of Chemotherapy-Induced Neuropathic Pain Save
- A Method of Synthesis of an Arylalkanoic Acid Derivative and a Product Thereof. Save
- Amynah Pradhan, Elizaveta Mangutov, Akhilesh Kotiyal, and Yaseen Awad Igbaria. PACAP and PAC1 Receptors Facilitate Opioid-Induced Hyperalgesia Save
- Targeting Endogenous delta-Opioid Receptor Modulation for Migraine and Opioid-Induced Hyperalgesia Save
- Dermorphin [D-Arg2, Lys4](1--4) Amide Attenuates Burn Pain by Inhibiting TRPV1/NR2B Mediated Neuroinflammatory Signalling Save
- Mechanism and modulation of spontaneous pain: from neural circuits to drug development Save
- TRPA1 siRNA-loaded nanoformulation ameliorates chemotherapy-induced peripheral neuropathy Save
- Virtual screening and molecular dynamics investigations using natural compounds against autotaxin for the treatment of chronic pain Save
- Caspase‐driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications Save
- Caspase-driven cancer therapies: Navigating the bridge between lab discoveries and clinical applications Save
- Correlation of surface properties with dissolution behavior of amorphous solid dispersion of riluzole and its pharmacodynamic evaluation Save
- Dermorphin [D-Arg2, Lys4](1-4) Amide Alleviates Frostbite-Induced Pain by Regulating TRP Channel-Mediated Microglial Activation and Neuroinflammation Save
- Development and validation of clinically Mimicable model of frostbite injury-induced chronic pain Save
- Fecal Microbiota Transplantation-Mediated Rebalancing of the Gut--Brain Axis Alleviates Cisplatin-Induced Neuropathic Pain Save
- Focal Adhesion Kinase Inhibition Ameliorates Burn Injury-Induced Chronic Pain in Rats Save
- Glucose regulation by newly synthesized boronic acid functionalized molecules as dipeptidyl peptidase IV inhibitor: a potential compound for therapeutic intervention in hyperglycaemia Save
- TLR-4: a promising target for chemotherapy-induced peripheral neuropathy Save