Pooja Jadiya
Atrium Health Wake Forest Baptist, Temple University, Central Drug Research Institute, Dr. Hari Singh Gour University, Rutgers, The State University of New Jersey
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Mitochondrial Function and Pathology · Alzheimer's disease research and treatments · Calcium signaling and nucleotide metabolism
0000-0003-4807-9304
About
I am a tenure-track Assistant Professor in the Department of Internal Medicine, Section on Gerontology and Geriatric Medicine at Wake Forest University School of Medicine. My research group is dedicated to Alzheimer's disease (AD) research in the field of mitochondrial biology, emphasizing mentoring future scientists. I have a strong commitment to mentoring and research training, reflected by my trainees’ 17 competitive awards, including multiple American Heart Association (AHA) postdoctoral and predoctoral fellowships and an AHA Career Development Award. I am actively engaged in scientific societies, including the Alzheimer's Association (ISTAART), American Society of Cell Biology (ASCB), and the American Heart Association. As a member of ASCB's Women in Cell Biology Committee, I focus on promoting scientific and career development, particularly among early-career researchers and women.
In my laboratory, we investigate the role and mechanisms of mitochondrial calcium (mCa2+) signaling, quality control pathways, and cell death in AD. My laboratory uses genetic, loss, and gain-of-function mutant mice, cutting-edge molecular imaging methodologies, calcium flux analysis, mass spectrometry-based profiling, rodent behavioral tests, AD phenotyping, mitochondrial function assays, and cellular metabolism measurements. I have been actively involved in discovering new molecular mechanisms underlying mCa2+ efflux and influx in AD and age-associated cognitive decline (Nature Communications, 2019a; bioRxiv. 2023; iScience 2023; Biochim Biophys Acta Mol Basis Dis. 2024). Additionally, I have contributed to uncovering the role of mitochondrial sodium/calcium exchanger in hypoxic redox signaling (Nature, 2020), mitochondrial micropeptides in cellular physiology (Cell Reports, 2018), mCa2+ exchange in epigenetic regulation (Nature Communications, 2019b), the role of mCa2+ uniporter beta subunit (MCUB) in cardiac physiology (Circulation, 2019), mechanisms of mitochondrial quality control (Genes, 2020, Front Cell Dev Biol , 2023, J Bio Chem, 2024), and the role of MICU1 in mitochondrial structure and function (Science Signaling 2023).
Employment
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Atrium Health Wake Forest Baptist Assistant Professor2022 - Present
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Temple University Instructor (Research)2020 - 2021
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Temple University Associate Scientist2020 - 2020
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Temple University Postdoctoral Fellow2015 - 2020
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Rutgers, The State University of New Jersey Postdoctoral Associate2015 - 2015
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Central Drug Research Institute Research Fellow2009 - 2015
Education
- 2009 - 2015
- 2006 - 2008
- 2003 - 2006
Projects & Funding
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Compartment-specific mitochondrial unfolded protein response in Alzheimer’s disease American Heart Association2025 - 2027
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Targeting mitochondrial calcium dynamics to mitigate Alzheimer’s disease pathology American Heart Association2025 - 2028
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Cellular heterogeneity in mitochondrial calcium dynamics in heart failure National Heart Lung and Blood Institute2025 - 2030
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Mitochondrial calcium heterogeneity in cerebrovascular system during Alzheimer's disease American Heart Association2024 - 2026
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Mitochondrial calcium uptake in Alzheimer’s disease National Institute on Aging2020 - 2025
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Mitochondrial calcium uptake in Alzheimer's disease National Institute on Aging2020 - 2022
Publications (58)
- Mitochondrial heterogeneity across cardiac cell types in heart failure with preserved ejection fraction Save
- Proteolytic control of mitochondrial calcium transport by intermembrane-space proteases Save
- Mitochondrial-nuclear crosstalk: A central axis in Alzheimer’s disease Save
- Lactylation landscape of mitochondrial proteins in myocardial infarction Save
- Correction: Cell-type-specific dysregulation of mitochondrial calcium signalingin Alzheimer’s disease Save
- Cell-type-specific dysregulation of mitochondrial calcium signaling in Alzheimer’s disease Save
- TRIM71 bound hsa-miR-30b-5p restores mitochondrial function in a cellular model of Parkinson's disease Save
- Mitochondrial connection to Alzheimer’s disease and heart failure Save
- Enhancing VEGF therapy in T2D wounds with PLCγ2 epigenetic targeting Save
- Calcium signaling in mitochondrial intermembrane space Save
- Abstract 1055 Mitochondrial disaggregase CLPB modulates MICOS complex and cristae ultrastructure Save
- Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [11C]MPC-6827 PET imaging in rodent models of Alzheimer's-related pathology Save
- MICOS Complex Loss Governs Age-Associated Murine Mitochondrial Architecture and Metabolism in the Liver, While Sam50 Dictates Diet Changes Save
- Mitochondrial calcium signaling in non-neuronal cells: Implications for Alzheimer's disease pathogenesis Save
- The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney Save
- Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline Save
- Genetic ablation of neuronal mitochondrial calcium uptake halts Alzheimer's disease progression Save
- MCU gain- and loss-of-function models define the duality of mitochondrial calcium uptake in heart failure Save
- MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca2+ uniporter channel Save
- Post-translational modifications and protein quality control of mitochondrial channels and transporters Save