0000-0003-4886-9234 About
Drug Discovery and Development: We aim at deciphering the role of natural compounds in the therapy of rheumatoid arthritis (RA) with prime emphasis on improving its efficacy.
Investigation of Anti-inflammatory activity in-vitro
In-vivo anti-arthritic model ( Collagen-induced arthritic model)
Mechanism of action
Preclinical development
• Complete in silico and in vitro determination of physicochemical parameters
• In vitro and in vivo Absorption, Distribution, Metabolism and Excretion (ADME)
• Drug-drug Interaction
• Transporter mediated and metabolism mediated drug-drug interaction and toxicity
• CYP-mediated metabolism
• In vivo Pharmacokinetics
Employment
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Indian Institute of Integrative Medicine Dr. Gurleen Kour (Research Associate)2020 - Present
Education
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Indian Institute of Integrative Medicine Ph.D
Projects & Funding
Projects & funding information is unavailable.
Publications (16)
- The multifaceted role of acetamide derivative of Chalcone: Anti-inflammatory Action and Impact on Osteoclastogenesis, insights on NF-κB and MAPK pathways Save
- An indole derivative of Ursolic acid, inhibits RANKL-induced osteoclast differentiation via modulating the Nrf2 and NFATc1/c-Fos axis: Targeting oxidative stress and osteoclastogenesis in managing rheumatoid arthritis Save
- Anti-inflammatory properties of allylic sulfone derivative: In vitro and in silico investigations using DFT and molecular dynamics Save
- Computational and biological evaluation of naphthofuran-based scaffold as an anti-inflammatory agent Save
- Design and synthesis of C-17 benzylidene derivatives of 14-deoxyandrographolide (14-DAG) and their TNF-α and IL-6 expression inhibitory activities Save
- Investigation of an aminothiazole-based scaffold as an anti-inflammatory agent: Potential application in the management of cytokine storm in SARS-CoV-19 Save
- Site-selective synthesis and pharmacological elucidation of novel semi-synthetic analogues of koenimbine as a potential anti-inflammatory agent Save
- Anti-inflammatory and anti-arthritic potential of methotrexate in combination with BA-25, an amino analogue of β-boswellic acid in the treatment of rheumatoid arthritis Save
- Anti-inflammatory Activity of Indole and Amide Derivatives of Ursolic Acid: Design, Synthesis, and Docking Studies Save
- Phytochemicals targeting JAK/STAT pathway in the treatment of rheumatoid arthritis: Is there a future? Save