0009-0002-5051-3253 About
I am a doctoral researcher in Biotechnology at Aligarh Muslim University, India, working at the intersection of protein biophysics, computational biophysics, and drug discovery. My research focuses on understanding the molecular mechanisms of protein misfolding and amyloid aggregation, with particular interest in α-synuclein and other amyloidogenic proteins associated with neurodegenerative and systemic amyloid diseases.
My research combines experimental biophysical approaches, including fluorescence spectroscopy, circular dichroism, calorimetry, and microscopy, with computational approaches such as molecular docking, molecular dynamics simulations, Markov State Modelling, molecular free-energy calculations, and virtual screening. I use these approaches to identify and mechanistically characterize small-molecule modulators of protein aggregation and investigate their potential for therapeutic intervention.
I have interdisciplinary research experience spanning protein misfolding, computational drug discovery, structural bioinformatics, and plant molecular biology, including research experience at Aligarh Muslim University and the Indian Institute of Science. I am also actively involved in scientific peer review and research mentorship.
Employment
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Aligarh Muslim University Doctoral Researcher2024 - Present
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Indian Institute of Science Bangalore Senior Research Fellow2020 - 2022
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Indian Institute of Science Bangalore Junior Research Fellow2018 - 2020
Education
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Aligarh Muslim University Ph.D.2024 - Present
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Aligarh Muslim University Master of Science2016 - 2018
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Aligarh Muslim University Bachelor of Science2012 - 2016
Projects & Funding
Projects & funding information is unavailable.
Publications (11)
- Levofloxacin-Induced Insulin Aggregation: Biophysical and Computational Insights into Amyloidogenic Potential Save
- Association of mercury exposure with neurodegenerative diseases - a reality or a misconception? Save
- Baicalein inhibits amyloid beta42 aggregation through disruption of the Asp23-Lys28 salt bridge Save
- Hippuric acid, a uremic toxin, binds to aggregation prone region of human lysozyme and potentiates the fibrillation: A biophysical insight Save
- Furosemide Derails Human Lysozyme Fibrillation by Interacting with Aggregation Hot Spots: A Biophysical Comprehension Save
- Investigation on the molecular interaction between dietary flavone luteolin and alpha-2-macroglobulin using multi-spectroscopic, calorimetric and molecular dynamics simulation techniques Save
- Natural compound plumbagin based inhibition of hIAPP revealed by Markov state models based on MD data along with experimental validations Save
- Small molecule inhibits BACE1 activity by a dual mechanism confirmed by simulations-based study Save
- A novel compound heterozygous BEST1 gene mutation in two siblings causing autosomal recessive bestrophinopathy Save
- Computational studies on phylogeny and drug designing using molecular simulations for COVID-19 Save