Charudatt Samant

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Publications (7)

• Drugging the Undruggable and beyond: Emerging precision oncology approaches to target acquired resistance to KRAS G12C and KRAS G12D inhibitors
  Biochemical and Biophysical Research Communications 2025 DOI: 10.1016/j.bbrc.2025.151688
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• Role of Wnt/β-catenin pathway in cancer drug resistance: Insights into molecular aspects of major solid tumors
  Biochemical and Biophysical Research Communications 2024 DOI: 10.1016/j.bbrc.2024.150348
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• Inhibition of SGK1 potentiates the anticancer activity of PI3K inhibitor in NSCLC cells through modulation of mTORC1, p‑ERK and β‑catenin signaling
  Biomedical Reports 2023 DOI: 10.3892/br.2023.1676
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• PAK4 inhibition significantly potentiates Gemcitabine activity in PDAC cells via inhibition of Wnt/β-catenin, p-ERK/MAPK and p-AKT/PI3K pathways
  Biochemistry and Biophysics Reports 2023 DOI: 10.1016/j.bbrep.2023.101544
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• Dual PI3Kδγ inhibition demonstrates potent anticancer effects in diffuse large B-cell lymphoma models: Discovery and preclinical characterization of LL-00084282.
  Biochemical and biophysical research communications 2022 DOI: 10.1016/j.bbrc.2022.11.038
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• Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis.
  European journal of pharmacology 2022 DOI: 10.1016/j.ejphar.2022.175054
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• Discovery of a Potent and Selective PI3Kδ Inhibitor (S)-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4H-quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Ca…
  Journal of medicinal chemistry 2020 DOI: 10.1021/acs.jmedchem.0c01264
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