Goraksha Khose

About

I am a PhD candidate in medicinal chemistry at the University of Iceland, with more than 15 years of experience in pharmaceutical research and development, medicinal chemistry, and synthetic organic chemistry.

My doctoral research focuses on the synthesis and biological evaluation of phenazine-based compounds targeting Mycobacterium tuberculosis and acute myeloid leukemia. My work explores structure–activity relationships and strategies to improve potency, selectivity, toxicity profiles, and metabolic stability.

My broader research interests include drug discovery, lead optimization, synthetic methodology, process development, and technology transfer. I am also interested in applying artificial intelligence, automation, and data-driven approaches to pharmaceutical research.

Employment

Employment history is unavailable.

Education

• University of Iceland PhD
  2022 - Present
• University of Pune MBA
  2019 - 2021
• University of Pune M.Sc
  2004 - 2006

Projects & Funding

Projects & funding information is unavailable.

Publications (9)

• New Phenazine 5,10-Dioxide Carbamates Inspired by Iodinin and Myxin Exhibit Improved Potency in Human Leukemia Cells with High Cytotoxic Selectivity, Activity against Mycobacterium Tuberculosis and Low Toxicity to Zebrafish Larvae
  Journal of Medicinal Chemistry 2026 DOI: 10.1021/acs.jmedchem.6c02599
  +Save
• Phenazine 5,10-dioxide analogues as potential therapeutics in AML: Efficacy on patient-derived blasts, in zebrafish larvae xenografts and synergy with venetoclax
  Translational Oncology 2026 DOI: 10.1016/j.tranon.2025.102628
  +Save
• Functionalized regioisomers of the natural product phenazines myxin and iodinin as potent inhibitors of Mycobacterium tuberculosis and human acute myeloid leukemia cells
  Goraksha Machhindra Khose, Siva Krishna Vagolu, Reidun Aesöy +9 more
  European Journal of Medicinal Chemistry 2025 DOI: 10.1016/j.ejmech.2025.117244
  +Save
• Preparation of THP derivatives for use as odorants
  2021
  +Save
• Preparation of tricyclic compound useful as ARA in medicinal applications such as treatment of cancer
  2019
  +Save
• Novel heterocyclic compounds having inhibitory action on binding of BET domain family
  2016
  +Save
• Synthesis of substituted esters of imidazoles, oxazoles, thiazoles, and diethyl pyrazine-2,5-dicarboxylate from a common acyclic precursor employing C-formylation strategy
  Tetrahedron Letters 2014 DOI: 10.1016/j.tetlet.2014.03.039
  +Save
• Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain l-2-hydroxy acid oxidase
  Dinesh A. Barawkar, Anish Bandyopadhyay, Anil M. Deshpande +23 more
  Bioorganic & Medicinal Chemistry Letters 2012 DOI: 10.1016/j.bmcl.2012.05.020
  +Save
• Potent and Selective Inhibitors of Long Chain <scp>l</scp>-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats
  Dinesh A. Barawkar, Ashwin Meru, Anish Bandyopadhyay +28 more
  ACS Medicinal Chemistry Letters 2011 DOI: 10.1021/ml2001938
  +Save