Shikha

About

I am a biotechnologist with a Ph.D. specializing in IgE antibody engineering and functional characterization of therapeutic antibodies. My research focuses on the design, glyco-engineering, and stability optimization of IgE-based antibody formats for cancer immunotherapy.

I have extensive experience in mammalian cell line engineering, reporter and potency assay development, and molecular and cellular biology, supported by computational tools such as molecular dynamics simulations. I have published as first and corresponding author in peer-reviewed journals and presented at major international scientific conferences.

My work bridges academic discovery and industrial application, with particular interest in novel antibody modalities, assay innovation, and translational biologics research.

Employment

• Curateq biologics Ltd. Associate Scientist
  2025 - Present
• Manipal Academy of Higher Education PhD Scholar
  2021 - Present
• Institute of Bioinformatics and Applied Biotechnology Senior Research Fellow
  2019 - 2024
• Syngene International (India) Research Associate
  2016 - 2018

Education

• Manipal Academy of Higher Education Ph.D

Projects & Funding

Projects & funding information is unavailable.

Publications (3)

• A Rational Design Strategy for Engineering CH4 Domain of IgE for Heterodimerization
  Biotechnology and Bioengineering 2026 DOI: 10.1002/bit.70068
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• IgE based therapeutics are an emerging modality in cancer treatment
  Discover Oncology 2025 DOI: 10.1007/s12672-025-03628-3
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• Systematic mutational analysis reveals an essential role of N275 in IgE stability
  Biotechnology and Bioengineering 2024 DOI: 10.1002/bit.28826
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