DEEPTANSHU PANDEY
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Protein Structure and Dynamics · Computational Drug Discovery Methods · Estrogen and related hormone effects
0009-0006-9571-3856
About
I am a Ph.D. researcher at the Department of Biological Sciences, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, India. My research focuses on understanding the evolutionary, structural, and network-level principles that govern protein function, stability, and biological system behaviour.
My work integrates evolutionary sequence analysis, protein structural dynamics, computational modelling, and biological network analysis to investigate how evolutionary constraints shape protein function and influence responses to mutations and pharmacological perturbations. My research interests include protein evolution and epistasis, structure–function relationships, molecular dynamics simulations, computational approaches to antimicrobial resistance, and network-based approaches to understanding drug interactions and synergistic effects in metabolic pathways.
Through an interdisciplinary approach combining computational biology, structural bioinformatics, and systems biology, I aim to develop mechanistic insights into the relationship between molecular evolution, protein function, and cellular network behaviour, with applications in antimicrobial research and the broader understanding of complex biological systems.
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Publications (6)
- Topological Complementarity Predicts Synergistic Drug Pairs in Branched Metabolic Networks Save
- Multiple dynamically-coupled binding sites on human serum albumin regulate estradiol's nonlinear binding Save
- Adaptive Landscapes of Plasmodium Falciparum Dihydrofolate Reductase Reveal Pathways to Antifolate Resistance Save
- Evolutionary and Structural Constraints Define a Mutation-Resistant Catalytic Core in E. coli Serine Hydroxy methyltransferase (SHMT) Save
- Integrated structural analysis of sex hormone binding globulin reveals allosteric modulation by distant mutations Save
- Mapping dihydropteroate synthase evolvability through identification of a novel evolutionarily critical substructure Save