Sai Chaitanya Kosana
Research areas: Chemistry · Organic Chemistry · Synthesis and biological activity · Synthesis and Characterization of Heterocyclic Compounds · Histone Deacetylase Inhibitors Research
0009-0008-8460-0957
About
Synthetic and medicinal chemist with doctoral research experience in small-molecule drug discovery from BITS-Pilani Hyderabad Campus. PhD research includes discovery of anti-virulence agents targeting quorum sensing and biofilms, development of non-hydroxamate HDAC inhibitors, isoform-selective inhibitor discovery, cellular target engagement studies, molecular docking, molecular dynamics and ADME-supported lead optimization. Pharmaceutical R&D experience at Syngene International Ltd., GVK Biosciences and BCRL, PCI. Expertise includes multi-step organic synthesis, heterocyclic chemistry, medicinal chemistry, structure–activity relationship development, biological evaluation and computationally supported drug design.
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Publications (13)
- Quinoline and Isoquinoline Analogs in Neuroprotection Save
- Design, Synthesis and Evaluation of Indole-Based 1,2,3-Triazoles as Potential Quorum Sensing and Biofilm Inhibitors Against Pseudomonas aeruginosa Save
- Discovery of cyanocarbonimidodithioates as novel non-hydroxamate zinc-binding groups for selective HDAC8 inhibition: Design, synthesis, biological evaluation, anticancer activity, and in silico studies Save
- Discovery of triazole-tethered glycinate and propanoate derivatives bearing a thiolactone moiety as quorum sensing inhibitors of Pseudomonas aeruginosa: design, synthesis, biological evaluation, and biofilm inhibition Save
- Exploration of non-hydroxamate based quinoline analogues as HDAC8 inhibitors Save
- Targeted HDAC8 inhibition with non-hydroxamate [1,2,4]triazolo[4,3-a] quinoline compounds Save
- Zinc based organic metal complexes for OLED applications Save
- Design and Synthesis of Novel Spiro [Chromane-2,4′-Piperidin]-4-One Derivatives: Anti-Proliferative Investigation and Molecular Docking Studies Save
- Design, synthesis, and biological evaluation of substituted benzyl-triazolopyridine derivatives as non-hydroxamate based HDAC8 inhibitors Save
- Exploring 4-morpholinopyrrolo-[2,3-d]-pyrimidine derivatives as novel anti-cancer agents: Design, synthesis and biological studies Save
- Design, synthesis and biological evaluation of novel pyrido-[2,3-d]-pyrimidin-2-amine analogues as antimycobacterial agents Save
- Design, synthesis, and biological evaluation of novel quinoxaline aryl ethers as anticancer agents Save
- Development and Biological Evaluation of Novel Spiro 4-Chromanones as Potent Quorum Sensing Inhibitors Save