Abhisek Ghosal
MDX Health, Lucid Diagnostics, Jadavpur University, University of Calcutta, NeoGenomics (United States)
0009-0009-1571-0754
About
Abhisek Ghosal, PhD, Molecular Diagnostics Assay Development Scientist.
Dr. Abhisek Ghosal is a molecular diagnostics scientist with almost two decades of experience in the molecular techniques, development and validation of clinical assays for oncology applications. He currently serves as a Product Development Scientist at MDxHealth, where his work centers on PCR- and next-generation sequencing–based diagnostics, analytical validation, and quality-driven assay development in regulated laboratory environments. He has upgraded his research application to next level by mastering machine learning and AI in diagnosis with solid understanding in statistics and scripting.
He earned his PhD in the area of Biochemistry and Molecular Microbiology from Jadavpur University, India and completed postdoctoral research at the University of California, Irvine. His professional experience spans in translational assay development across industry and academic settings.
He has authored few dozens of peer-reviewed publications and has presented his work at numerous International scientific conferences. He was awarded for Young Scientist award, Editorial Picks and travel awards for presenting research papers. He had been member of different scientific community as American Physiology Society, USA (APS), American Society for Microbiology, USA (ASM), American Gastroenterological Society, USA (AGA). He has been reviewer for Elsevier journals for almost 10 years. He has served as reviewer for almost hundred peer-reviewed publications across different publishing houses and journals.
His research work can be broadly categorized as follows.
1) Infectious Disease Research: His early research focused on host–pathogen interactions in enteric infections, particularly Escherichia coli, Vibrio cholerae, and Salmonella. His work combined molecular biology, protein characterization, and cellular models to understand bacterial colonization factors, intestinal adherence, and pathogen-induced disruption of host transport processes. These studies contributed to a clearer understanding of how microbial virulence mechanisms intersect with intestinal physiology and mucosal integrity.
2) Vitamin Transport & Intestinal Biology: A significant portion of his academic work examined the regulation and function of intestinal vitamin transporters, including biotin, riboflavin, pantothenate, and multivitamin transport systems. Using cellular models, knockout mouse systems, and molecular characterization approaches, his studies clarified transporter structure–function relationships and adaptive regulatory mechanisms under physiological and disease conditions. Several of these works were recognized as Editor’s Picks, reflecting their impact on the field of gastrointestinal and cellular physiology.
3) Oncology Diagnostics & Molecular Pathology: In recent years, Dr. Ghosal’s research has centered on molecular diagnostics for oncology, with an emphasis on analytical validation and real-world performance of NGS-based and methylation-based assays. His publications include multi-center evaluations of circulating tumor DNA sequencing platforms, cross-panel analytical benchmarking, and validation of DNA methylation biomarkers for early detection of Barrett’s esophagus and esophageal adenocarcinoma. This body of work highlights a consistent focus on assay robustness, clinical relevance, and reproducibility in regulated diagnostic settings.
Few of his works were published in American Journal of Physiology, JBC, Nature, Genome Biology, BBA, Plos One, Diagnostics, Microbiology, Journal of Clinical Microbiology, and BMC Cancer.
Employment
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MDX Health Diagnostics Product Development2024 - Present
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Lucid Diagnostics Principal Scientist2022 - 2024
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NeoGenomics (United States) Senior Scientist2021 - 2022
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ResearchDX Senior Scientist2017 - 2021
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Prodo Laboratories (United States) Research Scientist2015 - 2017
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University of California, Irvine Postdoctoral Fellow2010 - 2015
Education
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Jadavpur University Ph.D2004 - 2009
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University of Calcutta M.Sc2000 - 2002
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University of Calcutta B.Sc1996 - 2000
Projects & Funding
Projects & funding information is unavailable.
Publications (28)
- Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology Save
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions Save
- Analytical performance evaluation of a commercial next generation sequencing liquid biopsy platform using plasma ctDNA, reference standards, and synthetic serial dilution samples derived from normal plasma Save
- Biotin and pantothenic acid oversupplementation to conditional SLC5A6 KO mice prevents the development of intestinal mucosal abnormalities and growth defects Save
- Role of the sodium-dependent multivitamin transporter (SMVT) in the maintenance of intestinal mucosal integrity Save
- Characterization of oligomeric assembly of colonization factor CS6 from enterotoxigenic Escherichia coli Save
- Identification of residues/sequences in the human riboflavin transporter-2 that is important for function and cell biology Save
- Salmonella infection inhibits intestinal biotin transport: cellular and molecular mechanisms Save
- Molecular Mechanisms Mediating the Adaptive Regulation of Intestinal Riboflavin Uptake Process Save
- Identification and characterization of the minimal 5′-regulatory region of the human riboflavin transporter-3 (SLC52A3) in intestinal epithelial cells Save