ashok kumar

About

Dr. Ashok Kumar is working as a Research Assistant Professor under the mentorship of Prof. Jeffrey J. Hayes at the department of Biochemistry and Biophysics, University of Rochester, NY, USA. He received his Ph.D. (2013) in Molecular and Structural biology from Central Drug Research Institute/Jawaharlal Nehru University, India. His interest in exploring the networking of proteins and its signaling led him to pursue the research in cellular and molecular biology at the Hebrew University of Jerusalem (2012-20216) under the mentorship of Prof. Mona Dvir-Ginzberg. The work done in Prof. Dvir-Ginzberg lab provided a foundation for research in epigenetics and exploring the role of post translational modifications in gene regulation in diseases. He discovered novel post translational modification and its regulator in actin which is correlated with TAAD in Dr. Prabodh Kapoor group (2017-2020) while exploring the INO80 chromatin remodeling complex. The work done by him has been published in reputed journals like Cell Report, Aging Cell, Journal of Bone and Mineral Research, Journal of Cell Science (First person Interview as well), Frontiers in genetics etc. He is voluntarily reviewing manuscripts for journals like 3 biotech, Journal of Molecular science, Cells, Cell Proliferation etc. In addition Dr. Kumar is recipient of a competitive fellowship during his PhD and postdoc at the Hebrew University of Jerusalem, Israel. He presented his research in front of the scientific community from time to time in the international conferences.

Employment

• University of Rochester Research Assistant Professor
  2021 - Present
• University of Rochester Postdoctoral Research Associate
  2020 - 2021
• The University of Texas Health Science Center at Tyler Postdoctoral Research associate
  2017 - 2020
• Hebrew University Hadassah Medical School Postdoctoral Research fellow
  2012 - 2016

Education

• CSIR-Central Drug Research Institute Molecular and Structural Biology Division Structural studies of bacterial peptidyl-tRNA hydrolase
  2007 - 2012

Projects & Funding

Projects & funding information is unavailable.

Publications (22)

• Linker Histones: The Multiple Binding Modes of the Enigmatic 5th Histone
  Biomolecules 2026 DOI: 10.3390/biom16081181
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• A Rahman Syndrome mutation in histone H1.4 disrupts chromatin compaction and phase separation
  Nature Communications 2026 DOI: 10.1038/s41467-026-73046-8
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• Post-Translation Modifications and Mutations of Human Linker Histone Subtypes: Their Manifestation in Disease
  International Journal of Molecular Sciences 2023 DOI: 10.3390/ijms24021463
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• TNFα expression by Porphyromonas gingivalis ‐stimulated macrophages relies on Sirt1 cleavage
  Journal of Periodontal Research 2021 DOI: 10.1111/jre.12853
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• Sirtuins as NAD+-dependent deacetylases and their potential in medical therapy
  Medical Epigenetics 2021 DOI: 10.1016/b978-0-12-823928-5.00028-1
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• Actin R256 Mono-methylation Is a Conserved Post-translational Modification Involved in Transcription.
  Ashok Kumar, Yuan Zhong, Amelie Albrecht

  +20 more

  • Pau Biak Sang
  • Adrian Maples
  • Zhenan Liu
  • Vinesh Vinayachandran
  • Rohit Reja
  • +15 more
  Cell reports 2020 DOI: 10.1016/j.celrep.2020.108172
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• Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury.
  Cell proliferation 2020 DOI: 10.1111/cpr.12773
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• SIRT1 CLEAVAGE: FROM CARTILAGE DEGENERATION TO OSTEOARTHRITIC BIOMARKER
  Osteoarthritis and Cartilage 2019 DOI: 10.1016/J.JOCA.2019.02.150
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• The Nature of Actin-Family Proteins in Chromatin-Modifying Complexes
  2018 DOI: 10.3389/fgene.2018.00398
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• A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage
  Journal of Cell Science 2018 DOI: 10.1242/jcs.214973
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• First person - Ashok Kumar
  Journal of Cell Science 2018 DOI: 10.1242/JCS.223727
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• The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis
  Current Rheumatology Reports 2016 DOI: 10.1007/s11926-016-0591-y
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• SOX9 Acetylation Reduces Acan Expression in Adult Human Chondrocytes
  Aging cell 2016
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• Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes
  Aging Cell 2016 DOI: 10.1111/ACEL.12456
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• N-TERMINAL DOMAIN OF 75SIRT1 IS REQUIRED FOR CYTOCHROME C BINDING AND CELL SURVIVAL UNDER PRO-INFLAMMATORY STRESS
  Osteoarthritis and Cartilage 2016 DOI: 10.1016/J.JOCA.2016.01.350
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• NAD+-Dependent Deacetylases and Medical Therapy
  Medical Epigenetics 2016 DOI: 10.1016/B978-0-12-803239-8.00035-1
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• SOX9 ACETYLATION REDUCES AGGRECAN EXPRESSION IN ADULT HUMAN CHONDROCYTES
  Osteoarthritis and Cartilage 2016 DOI: 10.1016/J.JOCA.2016.01.302
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• Detecting cathepsin activity in human osteoarthritis via activity-based probes
  Arthritis Research and Therapy 2015 DOI: 10.1186/s13075-015-0586-5
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• NAD-dependent Deacetylases and Medical Therapy
  Medical Epigenetics, Elsevier publisher 2015
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• Set7/9 impacts col2a1 expression through binding and repression of sirT1 histone deacetylation
  Journal of Bone and Mineral Research 2014 DOI: 10.1002/jbmr.2052
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