Pauline Melenec

Employment

• EPFL - École Polytechnique Fédérale de Lausanne
  2019 - 2026
• EPFL - École Polytechnique Fédérale de Lausanne
  2019 - 2026
• Garvan Institute of Medical Research Research Assistant
  2016 - 2019
• IBDM Igenieur d'etude
  2011 - 2014

Education

• Polytech'Clermont-Ferrand Ingenieur en genie Biologique
  2007 - 2010

Projects & Funding

Projects & funding information is unavailable.

Publications (14)

• Targeting the NPY/NPY1R signaling axis in mutant p53–dependent pancreatic cancer impairs metastasis
  Science Advances 2025 DOI: 10.1126/sciadv.adq4416
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• Transfer of polarity information via diffusion of Wnt ligands in C. elegans embryos
  Current Biology 2024 DOI: 10.1016/j.cub.2024.03.030
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• The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation
  Nature 2024 DOI: 10.1038/s41586-024-07112-w
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• A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer
  Nature Cancer 2023 DOI: 10.1038/s43018-023-00614-y
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• Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse
  Science Advances 2023 DOI: 10.1126/sciadv.adf9063
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• Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging
  Cell Reports 2021 DOI: 10.1016/j.celrep.2021.109689
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• Structural mechanism of cGAS inhibition by the nucleosome
  Nature 2020 DOI: 10.1038/s41586-020-2750-6
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• Wnt ligands regulate the asymmetric divisions of neuronal progenitors in C. elegans embryos
  Development 2020 DOI: 10.1242/dev.183186
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• CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
  Claire Vennin, Pauline Mélénec, Romain Rouet +97 more
  Nature Communications 2019 DOI: 10.1038/s41467-019-10968-6
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• Removing physiological motion from intravital and clinical functional imaging data.
  eLife 2018 DOI: 10.7554/eLife.35800
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• Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer.
  James R. W. Conway, Sean C. Warren, David Herrmann +23 more
  Cell reports 2018 DOI: 10.1016/j.celrep.2018.05.038
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• Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.
  Claire Vennin, Venessa T. Chin, Sean C. Warren +49 more
  Science translational medicine 2017 DOI: 10.1126/scitranslmed.aai8504
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• Atypical Transcriptional Activation by TCF via a Zic Transcription Factor in C. elegans Neuronal Precursors.
  Developmental cell 2015 DOI: 10.1016/j.devcel.2015.04.018
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• Setting up a simple light sheet microscope for in toto imaging of C. elegans development.
  Journal of visualized experiments : JoVE 2014
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