BF
Benjamin Fairfax
University of Oxford
Research areas: Biochemistry, Genetics and Molecular Biology · Genetics · Genetic Associations and Epidemiology · Cancer Immunotherapy and Biomarkers · Epigenetics and DNA Methylation
0000-0001-7413-5002
Employment
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University of Oxford Principal Investigator
Education
Education history is unavailable.
Projects & Funding
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Characterising genetic determinants of response to immune checkpoint blockade at the single cell level Wellcome Trust2023 - 2028
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Inflammation associated modulation of DNA methylation: An investigation into the genetic determinants and transcriptional consequences Wellcome Trust2017 - 2022
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Multi-parametric characterisation of peripheral immunity in recipients of checkpoint immunotherapy across a large patient cohort Engineering and Physical Sciences Research Council2017 - 2021
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A pilot investigation into genotypic determinants of melanocyte transcription, epigenetics and response to ultraviolet radiation. Academy of Medical Sciences2015 - Present
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Identification and functional characterisation of genetic variation regulatingtolerance to Toll-like receptor activation. Wellcome Trust2009 - 2013
Publications (122)
- Peripheral Biomarkers and Determinants of Survival for Patients with Melanoma Brain Metastasis Treated with Immune Checkpoint Blockade Save
- Genetic determinants of cytokine production in activated human monocytes Save
- Lactation, tissue-resident immunity, and protection against breast cancer Save
- The immunomodulatory role of human cytomegalovirus in cancer in the era of checkpoint immunotherapy Save
- Genetic determinants of monocyte splicing are enriched for disease susceptibility loci Save
- Defining the genetic determinants of CD8+ T cell receptor repertoire in the context of immune checkpoint blockade Save
- CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade. Save
- Defining the genetic determinants of CD8+T cell receptor repertoire in the context of immune checkpoint blockade Save
- Genetic determinants of monocyte splicing are enriched for disease susceptibility loci including for COVID-19 Save
- An isoform quantitative trait locus in SBNO2 links genetic susceptibility to Crohn’s disease with defective antimicrobial activity Save
- IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma. Save
- Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity. Save
- Genetic variation at IL7 provides mechanistic insights into toxicity to immune checkpoint blockade Save
- Changes in epigenetic profiles throughout early childhood and their relationship to the response to pneumococcal vaccination Save
- Sensitivity to Immune Checkpoint Blockade and Progression-Free Survival is associated with baseline CD8+ T cell clone size and cytotoxicity Save
- A blood atlas of COVID-19 defines hallmarks of disease severity and specificity Save
- Changes in epigenetic profiles throughout early childhood and their relationship to the response to pneumococcal vaccination Save
- Checkpoint-blocker-induced autoimmunity is associated with favourable outcome in metastatic melanoma and distinct T-cell expression profiles Save
- EPISPOT: an epigenome-driven approach for detecting and interpreting hotspots in molecular QTL studies Save
- IFN$γ$-producing CD8+ tissue resident memory T cells are a targetable hallmark of immune checkpoint inhibitor-colitis Save