TK
Thomas Köhnke
Research areas: Medicine · Hematology · Acute Myeloid Leukemia Research · Immunotherapy and Immune Responses · Cancer Immunotherapy and Biomarkers
0000-0001-7454-6282
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Publications (54)
- DNMT3A R882H Is Not Required for Disease Maintenance in Primary Human AML but Is Associated with Increased Leukemia Stem Cell Frequency Save
- Intra-Leukemic Interferon Signaling Suppresses Expansion and Mediates Chemoresistance in Human AML Save
- A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis Save
- Quantification of intrinsic regulatory factors refines human hematopoietic progenitor definitions and reveals early erythroid lineage priming. Save
- ASXL1 truncating mutations drive leukemic resistance to T cell attack Save
- A CEBPB/IL-1β/TNF-α Feedback Loop Drives Drug Resistance to Venetoclax and MDM2 Inhibitors in Monocytic Leukemia. Save
- A new era of functional experimentation in human hematopoiesis and leukemia research Save
- DNMT3AR882H Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated With Increased Leukemia Stem Cell Frequency Save
- Human ASXL1-Mutant Hematopoiesis Is Driven by a Truncated Protein Associated with Aberrant Deubiquitination of H2AK119 Save
- Convergent epigenetic evolution drives relapse in acute myeloid leukemia. Save
- IDH1-Mutant Preleukemic Hematopoietic Stem Cells Can Be Eliminated by Inhibition of Oxidative Phosphorylation Save
- ASXL1 Truncating Mutations Drive Leukemic Resistance to T Cell Attack Save
- BCOR Loss Confers Increased Stemness and Partially Rescues RUNX1-Deficient Phenotypes in Human Hematopoietic Stem and Progenitor Cells Save
- Cebpβ/IL1/TNFα Positive Feedback Loop Drives Drug Resistance of BCL2 and MDM2 Inhibitors in Monocytic Leukemia Cells Save
- Engineering Sequential Mutations into Human HSPCs Yields an Aggressive Myeloid Malignancy Allowing for Interrogation of Preleukemic Transformation Save
- Gene Correction of DNMT3A:R882H in Primary Human AML Demonstrates That This Mutation Is Not Required for Disease Maintenance, but Is Associated with Increased Leukemia Stem Cell Frequency Save
- Intra-Leukemic IFN. Signaling Mediates Cell Cycle Suppression and Chemoresistance in AML Save
- Serum Amyloid A1 (SAA1) Secreted By the Stromal Microenvironment Drives Malignant Clonal Proliferation in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) Save
- RUNX1 loss renders hematopoietic and leukemic cells dependent on IL-3 and sensitive to JAK inhibition Save
- Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy Save