Pushparaj P
Research areas: Medicine · Reproductive Medicine · Sperm and Testicular Function · Mast cells and histamine · Asthma and respiratory diseases
0000-0001-7574-1880
About
Dr. Peter Natesan Pushparaj received his Ph.D. in biochemistry in 2005 from the National University of Singapore (NUS), one of the top universities in the world (ranked 8th in the QS world university rankings (2023), ranked 19th in the latest Times Higher Education (THE) Rankings, 2023). During his post-doctoral fellowship, he extensively investigated signal transduction pathways using functional genomics, immunopharmacology, and systems immunology approach to identify various "druggable" molecular targets and drugs for allergy, anaphylaxis, asthma, and rheumatoid arthritis. This has led to high-impact publications in Tier 1 journals such as Nucleic Acids Research, Antioxidants & Redox Signaling, Frontiers in Immunology, Nature Medicine, Frontiers in Pharmacology Frontiers in Cell and Developmental Biology, Frontiers in Pediatrics, Journal of Immunology, Journal of Dental Research (the world's leading journal in Oral Biology and Medicine), Cellular and Molecular Life Sciences (CMLS), FASEB J, Neuroscience, etc. He has also used RNA interference (RNAi) as a tool to identify and validate "druggable" molecular targets in in vitro and in vivo model systems. He is currently investigating the mechanism of action of novel drugs, novel cytokines, and natural products using in vitro, in vivo, and in silico model systems for infections such as COVID -19, immunity, and inflammation. He has also edited a book on Nobel Prize-winning RNA interference technology and published several book chapters in various books by prominent scientists in biomedical sciences. To date, 41 of his articles have been cited in patents listed in the Derwent Innovation Index and his articles were cited 122 times in all types of patents based on Lens Profiles.
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Publications (217)
- Deciphering the Dysregulated Pathways and Candidate Therapeutic Compounds for Primary Ovarian Cancer Using Whole Transcriptomics Data and Next Generation Knowledge Discovery Strategies Save
- Correction: Alzahrani et al. Propranolol and Capecitabine Synergy on Inducing Ferroptosis in Human Colorectal Cancer Cells: Potential Implications in Cancer Therapy. Cancers 2025, 17, 1470 Save
- Propranolol and Capecitabine Synergy on Inducing Ferroptosis in Human Colorectal Cancer Cells: Potential Implications in Cancer Therapy Save
- Untangling the complex mechanisms associated with Alzheimer's disease in elderly patients using high-throughput RNA sequencing data and next-generation knowledge discovery methods: Focus on potential gene signatures and drugs for dementia Save
- The mutational spectrum of NRAS gene discovers a novel frameshift mutation (E49R) in Saudi colorectal cancer patients Save
- The roles of FGFR, EGFR and AMP-activated protein kinase pathway in colorectal cancer stem cells derived spheroids: Implications in colorectal cancer treatment Save
- Evaluation of serum biomarkers after intra-articular injection of rat bone marrow-derived mesenchymal stem cells in a rat model of knee osteoarthritis Save
- Current genetic models for studying congenital heart diseases: Advantages and disadvantages. Save
- Synthesis and molecular docking analysis of MBH adducts' derived amides as potential β-lactamase inhibitors. Save
- Screening, awareness and challenges for colorectal cancer treatment in Saudi Arabia: an update. Save
- Acute and chronic impact of interleukin-33 stimulation on chemokines and growth factors in human cord blood-derived mast cells Save
- Acute and prolonged effects of interleukin-33 on cytokines in human cord blood-derived mast cells Save
- Deciphering gene expression signatures in liver metastasized colorectal cancer in stage IV colorectal cancer patients Save
- Discovery of a novel mutation F184S (c.551T>C) in GATA4 gene causing congenital heart disease in a consanguineous Saudi family Save
- Interleukin-33 mediated regulation of microRNAs in human cord blood-derived mast cells: Implications for infection, immunity, and inflammation Save
- The differential regulation of tumor suppressor genes (SAMD9, SPRED1, TGFBI, DUSP6, CDX2, TP53) and MAPK/ERK signaling pathway in colorectal cancer Save
- The discovery and simulation analysis of a novel mutation c.40 G < T (V14F) in the NRAS gene in patients with colorectal cancer in Saudi Arabia Save
- Leber hereditary optic neuropathy presenting as bilateral visual loss and white matter disease. Save
- Integration of palliative care in the management of oral squamous cell carcinoma. Save
- 5-Fluorouracil and capecitabine therapies for the treatment of colorectal cancer (Review) Save