Dr Amol Mhetre

About

I am a Synthetic Organic and Medicinal Chemist with expertise in the multi-step synthesis of natural products, target molecules, and their structure-activity relationship (SAR) studies. I have developed photo-affinity chemical probes for chemical proteomics platforms, as well as synthetic methodologies for biomolecules such as phospholipids and antibody-drug conjugates (ADCs). My research interests encompass the design and synthesis of biologically active compounds and small molecules for drug discovery and chemical biology research. Currently, my work focuses on structure-based drug design, the development of chemical probes, and small molecules targeting cancer and aging-related diseases.

Employment

• University of Michigan Research Investigator
  2026 - Present
• University of Michigan Sr. Research Fellow
  2023 - 2026
• Purdue University Postdoctoral Research Associate
  2022 - 2023
• Indian Institute of Science Education and Research Pune Postdoctoral Research associate
  2017 - 2022
• Sai Life Science Research Chemist
  2011 - 2012
• Jubilant Life Sciences (India) Research associate
  2009 - 2011
• United Phosphorous Ltd Trainee Chemist
  2008 - 2009

Education

• Sejong University PhD
  2012 - 2017
• Savitribai Phule Pune University Master of Science (M.Sc.)
  2006 - 2008

Projects & Funding

Projects & funding information is unavailable.

Publications (13)

• Chemoproteomics identifies protein ligands for monoacylglycerol lipids
  Communications Chemistry 2025 DOI: 10.1038/s42004-025-01589-w
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• Chemical Proteomics Identifies Protein Ligands for Monoacylglycerol Lipids
  2024 DOI: 10.1101/2024.12.22.629584
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• Benzoselenophene-based compounds, pharmaceutical compositions and antibody-drug conjugates including the same
  US Patent 2023
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• Selection methods for proximity-dependent enrichment of ligands from DNA-encoded libraries using enzymatic fusion proteins
  Chemical Science 2023 DOI: 10.1039/d2sc05495g
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• Enzyme-mediated proximity labeling for enrichment of DNA-linked ligands from DNA-encoded libraries
  2022 DOI: 10.26434/chemrxiv-2022-l097f
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• Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs
  Cell Chemical Biology 2021 DOI: 10.1016/j.chembiol.2021.01.008
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• A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster
  Biochemistry 2021 DOI: 10.1021/acs.biochem.1c00171
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• Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition
  Transgenic Research 2020 DOI: 10.1007/s11248-020-00219-6
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• The Lysophosphatidylserines—An Emerging Class of Signalling Lysophospholipids
  The Journal of Membrane Biology 2020 DOI: 10.1007/s00232-020-00133-2
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• Synthesis and biological evaluation of potent benzoselenophene and heteroaromatic analogues of (S)-1-(chloromethyl)-8-methoxy-2,3-dihydro-1H-benzo[e]indol-5-ol (seco-MCBI)
  RSC Advances 2019 DOI: 10.1039/c9ra04749b
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