Dr Amol Mhetre
University of Michigan, Purdue University West Lafayette, Sejong University, Savitribai Phule Pune University, Indian Institute of Science Education and Research Pune
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Sphingolipid Metabolism and Signaling · Lipid metabolism and biosynthesis · Click Chemistry and Applications
0000-0001-8644-8188
About
I am a Synthetic Organic and Medicinal Chemist with expertise in the multi-step synthesis of natural products, target molecules, and their structure-activity relationship (SAR) studies. I have developed photo-affinity chemical probes for chemical proteomics platforms, as well as synthetic methodologies for biomolecules such as phospholipids and antibody-drug conjugates (ADCs). My research interests encompass the design and synthesis of biologically active compounds and small molecules for drug discovery and chemical biology research. Currently, my work focuses on structure-based drug design, the development of chemical probes, and small molecules targeting cancer and aging-related diseases.
Employment
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University of Michigan Research Investigator2026 - Present
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University of Michigan Sr. Research Fellow2023 - 2026
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Purdue University Postdoctoral Research Associate2022 - 2023
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Indian Institute of Science Education and Research Pune Postdoctoral Research associate2017 - 2022
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Sai Life Science Research Chemist2011 - 2012
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Jubilant Life Sciences (India) Research associate2009 - 2011
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United Phosphorous Ltd Trainee Chemist2008 - 2009
Education
- 2012 - 2017
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Savitribai Phule Pune University Master of Science (M.Sc.)2006 - 2008
Projects & Funding
Projects & funding information is unavailable.
Publications (13)
- Chemoproteomics identifies protein ligands for monoacylglycerol lipids Save
- Chemical Proteomics Identifies Protein Ligands for Monoacylglycerol Lipids Save
- Benzoselenophene-based compounds, pharmaceutical compositions and antibody-drug conjugates including the same Save
- Selection methods for proximity-dependent enrichment of ligands from DNA-encoded libraries using enzymatic fusion proteins Save
- Enzyme-mediated proximity labeling for enrichment of DNA-linked ligands from DNA-encoded libraries Save
- Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs Save
- A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster Save
- Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition Save
- The Lysophosphatidylserines—An Emerging Class of Signalling Lysophospholipids Save
- Synthesis and biological evaluation of potent benzoselenophene and heteroaromatic analogues of (S)-1-(chloromethyl)-8-methoxy-2,3-dihydro-1H-benzo[e]indol-5-ol (seco-MCBI) Save
- A chemical–genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase Save
- Biochemical characterization of the PHARC-associated serine hydrolase ABHD12 reveals its preference for very-long-chain lipids Save
- Synthesis and anticancer activity of benzoselenophene and heteroaromatic derivatives of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI) Save