Chander Singh Digwal

About

I have extensive knowledge of organic and medicinal chemistry and its proper applications for developing target-specific chemical probes, target validation, and establishing structure-activity relationships (SAR) as well as a keen understanding of what is required to transform a molecule into a drug.

Employment

• Memorial Sloan Kettering Cancer Center Research Associate
  2021 - Present
• Memorial Sloan-Kettering Cancer Center Research Fellow
  2018 - 2021

Education

• National Institute of Pharmaceutical Education and Research Hyderabad Ph. D.
  2012 - 2017
• National Institute of Pharmaceutical Education and Research Ahmedabad M. S.
  2010 - 2012
• Mohanlal Sukhadia University B. Pharm
  2006 - 2010

Projects & Funding

Projects & funding information is unavailable.

Publications (29)

• Synthesis and Characterization of Click Chemical Probes for Single-Cell Resolution Detection of Epichaperomes in Neurodegenerative Disorders
  Sadık Bay, Chander Singh Digwal, Ananda M. Rodilla Martín +16 more
  Biomedicines 2024 DOI: 10.3390/biomedicines12061252
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• Unraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Occupancy and Extended Residence Time at the Site of Action
  Sahil Sharma, Suhasini Joshi, Teja Muralidhar Kalidindi +6 more
  Biomedicines 2023 DOI: 10.3390/biomedicines11102599
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• Editorial: Development of selective carbon-11 radioligands for target-based PET molecular imaging in oncology, cardiology and neurology
  Sridhar Goud Nerella, Manoj Kumar, Kiran Kumar Solingapuram Sai +1 more
  Frontiers in Medicine 2023 DOI: 10.3389/FMED.2023.1137088
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• How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view
  Structure 2023 DOI: 10.1016/J.STR.2023.05.017
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• Synthesis, biological evaluation and mechanistic studies of 4-(1,3-thiazol-2-yl)morpholine-benzimidazole hybrids as a new structural class of antimicrobials
  Shams Aaghaz, Chander Singh Digwal, Naziya Neshat +5 more
  Bioorganic Chemistry 2023 DOI: 10.1016/J.BIOORG.2023.106538
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• Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
  Nature Communications 2023 DOI: 10.1038/S41467-023-39241-7
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• Disease-specific interactome alterations via epichaperomics: the case for Alzheimer’s disease
  Stephen D. Ginsberg, Thomas A. Neubert, Sahil Sharma +5 more
  FEBS Journal 2022 DOI: 10.1111/febs.16031
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• Epichaperomes as a Gateway to Understanding, Diagnosing, and Treating Disease Through Rebalancing Protein–Protein Interaction Networks
  Protein Homeostasis in Drug Discovery 2022 DOI: 10.1002/9781119774198.CH1
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• How Aberrant <italic>N</italic>-Glycosylation Can Alter Protein Functionality and Ligand Binding: an Atomistic View
  BioRxiv 2022 DOI: 10.1101/2022.12.22.521543
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• PET Molecular Imaging in Drug Development: The Imaging and Chemistry Perspective
  Sridhar Goud Nerella, Priti Singh, Tulja Sanam

  +1 more

  • Chander Singh Digwal
  Frontiers in Medicine 2022 DOI: 10.3389/fmed.2022.812270
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• Synthesis of 124I-labeled epichaperome probes and assessment in visualizing pathologic protein-protein interaction networks in tumor bearing mice
  STAR Protocols 2022 DOI: 10.1016/j.xpro.2022.101318
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• Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
  Nature Communications 2021 DOI: 10.1038/s41467-021-24821-2
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• Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
  Communications Biology 2021 DOI: 10.1038/s42003-021-02842-3
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• A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond
  Tony Taldone, Tai Wang, Anna Rodina +10 more
  Cold Spring Harbor Perspectives in Biology 2020 DOI: 10.1101/CSHPERSPECT.A034116
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• Chemical probes and methods for single-cell detection and quantification of epichaperomes in hematologic malignancies
  Swathi Merugu, Sahil Sharma, Justin D. Kaner +6 more
  Methods in Enzymology 2020 DOI: 10.1016/BS.MIE.2020.04.057
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• Design and Synthesis of 5-Morpholino-Thiophene-Indole/ Oxindole Hybrids as Cytotoxic Agents
  Upasana Yadav, Akash P. Sakla, Ramya Tokala +7 more
  ChemistrySelect 2020 DOI: 10.1002/SLCT.201904845
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• Biomarker based targeting of the epichaperome as a novel therapeutic approach for Multiple Myeloma (MM)
  Clinical Lymphoma Myeloma and Leukemia 2019 DOI: 10.1016/J.CLML.2019.09.208
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• Synthesis and exploration of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives for their effects against carbonic anhydrase I, II, IX and XII isoforms as a non-sulfonamide class of inhibitors
  Baijayantimala Swain, Chander Singh Digwal, Andrea Angeli +4 more
  Bioorganic & Medicinal Chemistry 2019 DOI: 10.1016/J.BMC.2019.115090
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• Curcumin inspired 2-chloro/phenoxy quinoline analogues: Synthesis and biological evaluation as potential anticancer agents
  Bioorganic & Medicinal Chemistry Letters 2018 DOI: https://doi.org/10.1016/j.bmcl.2018.01.070
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• Synthesis and biological evaluation of curcumin inspired imidazo[1,2-a]pyridine analogues as tubulin polymerization inhibitors
  European Journal of Medicinal Chemistry 2018 DOI: https://doi.org/10.1016/j.ejmech.2017.11.010
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