Yudibeth Sixto-López
Universidad de Granada, Becerril Coca and Becerril, Instituto Politécnico Nacional, Instituto Politécnico Nacional Escuela Superior de Medicina, Consorcio Universidad Nacional Autonoma de Mexico
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Histone Deacetylase Inhibitors Research · Computational Drug Discovery Methods · Protein Structure and Dynamics
0000-0001-8903-3834
About
Translational medicinal chemist with expertise in drug discovery, computational modelling and the design of innovative therapeutic strategies for rare and metabolic diseases. My research integrates medicinal chemistry, molecular modelling and experimental validation to identify and optimize novel therapeutic candidates with translational potential.
My scientific career has evolved from epigenetic drug discovery and HDAC inhibitor development towards the exploration of multifunctional therapeutic approaches, including dual-target modulation and targeted protein degradation. I have contributed to international collaborative projects resulting in peer-reviewed publications, patented inventions and competitive research funding.
My current research focuses on developing multifunctional therapeutic strategies, including dual enzyme inhibition and targeted protein degradation, integrating computational modelling, chemical synthesis and experimental validation.
Employment
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Universidad de Granada postdoctoral fellow2024 - Present
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Universidad de Granada Postdoctoral research2021 - 2023
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Becerril Coca and Becerril patent consultatn2020 - 2021
Education
- 2016 - 2020
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Instituto Politécnico Nacional Escuela Superior de Medicina M.Sc. Pharmacology2011 - 2013
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Consorcio Universidad Nacional Autonoma de Mexico B.Sc. Chemist Pharmaceutical Biological2005 - 2010
Projects & Funding
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Synthesis, design and biological evaluation of HDAC inhibitors for the treatment of glioblastoma multiforme Secretaría de Educación, Ciencia, Tecnología e Innovación de la Ciudad de México2021 - 2023
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Synthesis, design and biological evaluation of HDAC inhibitors CONACYT2017 - 2017
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Synthesis, design and biological evaluation of HDAC inhibitors CONACYT2016 - 2020
Publications (39)
- Targeting Oxalate Production by Combining Enzyme Inhibition and Proteolysis Activation: A Novel Therapeutic Approach for Primary Hyperoxaluria Type 1 Save
- Molecular dynamics, docking and quantum calculations reveal conformational changes influenced by CYP271A amino acid mutations related to cerebrotendinous xanthomatosis Save
- Synthesis, Spectroscopic Characterization, Drug-Likeness, and Antibacterial Activity of a Novel Triazole Derivative Save
- Targeting Oxalate Overproduction: From Rare Genetic Disorders to Common Cardiometabolic Diseases Save
- Daidzein and Equol: Ex Vivo and In Silico Approaches Targeting COX-2, iNOS, and the Canonical Inflammasome Signaling Pathway Save
- Editorial: Use of computational tools for designing epigenetic drugs Save
- Molecular insight into endosulfan degradation by Ese protein from Arthrobacter: Evidence-based structural bioinformatics and quantum mechanical calculations Save
- Solvation effects, structural, vibrational analysis, chemical reactivity, nanocages, ELF, LOL, docking and MD simulation on Sitagliptin Save
- Synthesis, Solvent effects, Chemical reactivity, Molecular Docking and Molecular Dynamic Studies of Triazole derivative Save
- HISTONE DEACETYLASE INHIBITING COMPOUNDS (IHDAC) DERIVED FROM HYDROXAMIC ACIDS AND THEIR USE AS AGENTS FOR TREATING GLIOMAS. Save
- Cytotoxic evaluation of YSL-109 in a triple negative breast cancer cell line and toxicological evaluations Save
- Design and simulation of a caprylic acid enzymatically modified phosphatidylcholine micelle using a coarse-grained molecular dynamics simulations approach Save
- An investigation on the molecular structure, interaction with metal clusters, anti-Covid-19 ability of 2-deoxy-D-glucose: DFT calculations, MD and docking simulations Save
- Computational study of DMPC liposomes loaded with the N-(2-Hydroxyphenyl)-2-propylpentanamide (HO-AAVPA) and determination of its antiproliferative activity in vitro in NIH-3T3 cells Save
- Dihydropyrazole-Carbohydazide Derivatives with Dual Activity as Antioxidant and Anti-Proliferative Drugs on Breast Cancer Targeting the Hdac6 Save
- Dihydropyrazole-Carbohydrazide Derivatives with Dual Activity as Antioxidant and Anti-Proliferative Drugs on Breast Cancer Targeting the HDAC6 Save
- HDAC Inhibition as Neuroprotection in COVID-19 Infection Save
- In silico design of HDAC6 inhibitors with neuroprotective effects Save
- Synthesis, characterization, molecular docking and molecular dynamics simulations of benzamide derivatives as potential anti-ovarian cancer agents Save
- Targeting Several Biologically Reported Targets of Glioblastoma Multiforme by Assaying 2D and 3D Cultured Cells Save