DS
David Saliba
University of Malta, University of Oxford
Research areas: Immunology and Microbiology · Immunology · Immune Response and Inflammation · T-cell and B-cell Immunology · Cellular transport and secretion
0000-0001-9523-0586
Employment
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University of Malta Associate Professor2017 - Present
Education
Education history is unavailable.
Projects & Funding
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Mapping the immune landscape to assess immunotherapeutic strategies for treatment of Pituitary neuroendocrine tumours ECRF2021 - Present
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Accelerated antiviral therapeutics by phage display Malta Council For Science and Technology2021 - 2023
Publications (21)
- Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse Save
- T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles Save
- A novel population of activated cytotoxic T cells infiltrate pituitary neuroendocrine tumour subytpes Save
- RNA profiling of human growth hormone-secreting and non-functioning pituitary adenomas reveals novel and differentially expressed immune related genes Save
- Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse through distinct adaptors Save
- Tyrosol, at the Concentration Found in Maltese Extra Virgin Olive Oil, Induces HL-60 Differentiation towards the Monocyte lineage Save
- Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells. Save
- T-cell synaptic ectosomes relay signals through microcluster transfer Save
- TFH-derived dopamine accelerates productive synapses in germinal centres. Save
- Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis. Save
- IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans. Save
- A critical role for IRF5 in regulating allergic airway inflammation. Save
- IRF5 controls both acute and chronic inflammation. Save
- IRF5:RelA interaction targets inflammatory genes in macrophages. Save
- Cross-species analysis reveals evolving and conserved features of the nuclear factor κB (NF-κB) proteins. Save
- KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages. Save
- FOXO3 as a new IKK-ε-controlled check-point of regulation of IFN-β expression. Save
- Extensive characterization of NF-κB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits. Save
- Disturbed blood flow induces RelA expression via c-Jun N-terminal kinase 1: a novel mode of NF-κB regulation that promotes arterial inflammation. Save
- IRF5 is required for late-phase TNF secretion by human dendritic cells. Save