GC
Guoliang Chai
Chinese Institutes for Medical Research, Xuanwu Hospital, Capital Medical University, Universite Catholique de Louvain Institut de Neuroscience, Tsinghua University School of Life Sciences
Research areas: Biochemistry, Genetics and Molecular Biology · Genetics · Genetics and Neurodevelopmental Disorders · Multiple Sclerosis Research Studies · Developmental Biology and Gene Regulation
0000-0001-9658-6381
Employment
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Chinese Institutes for Medical Research Principal Investigator2024 - Present
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Xuanwu Hospital, Capital Medical University Professor2021 - Present
- 2015 - 2021
Education
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Universite Catholique de Louvain Institut de Neuroscience PhD2010 - 2015
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Tsinghua University School of Life Sciences Master2007 - 2010
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Tsinghua University Bachelor2003 - 2007
Projects & Funding
Projects & funding information is unavailable.
Publications (26)
- Microglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model. Save
- Biallelic FRA10AC1 variants cause a neurodevelopmental disorder with growth retardation. Save
- Somatic mosaicism reveals clonal distributions of neocortical development. Save
- Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. Save
- Developmental and temporal characteristics of clonal sperm mosaicism. Save
- A human pleiotropic multiorgan condition caused by deficient Wnt secretion Save
- Biallelic hypomorphic mutations in HEATR5B, encoding HEAT repeat-containing protein 5B, in a neurological syndrome with pontocerebellar hypoplasia Save
- Biallelic variants in HPDL, encoding 4-hydroxyphenylpyruvate dioxygenase-like protein, lead to an infantile neurodegenerative condition Save
- Erratum: Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen-storage-associated mitochondriopathy (The American Journal of Human Genetics (2021) 108(7) (1301–1317), (S0002929721001877), (10.1016/j.ajhg… Save
- Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen-storage-associated mitochondriopathy Save
- Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Save
- Somatic mosaicism in the mature brain reveals clonal cellular distributions during cortical development Save
- Challenges of misdiagnosis and suboptimal treatment of persistent idiopathic facial pain and atypical odontalgia: A retrospective multi-centric cross-sectional investigation Save
- A newly discovered mechanism driving neuronal mutations in Alzheimer's disease. Save
- Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome Save
- Erratum: Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome (The American Journal of Human Genetics (2018) 103(3) (431–439)(S0002929718302374)(10.1016/j.ajhg.2018.07.… Save
- Mutations in LNPK, Encoding the Endoplasmic Reticulum Junction Stabilizer Lunapark, Cause a Recessive Neurodevelopmental Syndrome Save
- Mutations in GPAA1, Encoding a GPI Transamidase Complex Protein, Cause Developmental Delay, Epilepsy, Cerebellar Atrophy, and Osteopenia Save
- Celsr3 and Fzd3 organize a pioneer neuron scaffold to steer growing thalamocortical axons Save
- Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling Save