Janardhan Keshav Karapurkar

Employment

• Boston University Postdoctoral Associate
  2024 - Present
• Hanyang University Postdoctoral Researcher
  2023 - 2024
• Hanyang University Ms-PhD student
  2018 - 2023
• Syngene International Ltd
  2016 - 2018

Education

• Hanyang University PhD.
  2018 - 2023

Projects & Funding

Projects & funding information is unavailable.

Publications (19)

• LATS1/2 inactivation drives a distinct venous endothelial cell response that contributes to fibrotic remodeling of the lung
  Science Advances 2026 DOI: 10.1126/sciadv.aef8468
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• An Efficient Endothelial Cell Differentiation Protocol Using Bioactive Lipid O-Cyclic Phytosphingosine-1-Phosphate in Human Embryonic Stem Cells
  International Journal of Stem Cells 2025 DOI: 10.15283/ijsc24068
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• Loss of Ubiquitin-Specific Protease 11 Mitigates Pulmonary Fibrosis in Human Pluripotent Stem Cell-Derived Alveolar Organoids
  International Journal of Stem Cells 2025 DOI: 10.15283/ijsc25011
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• USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells.
  Janardhan Keshav Karapurkar, Jencia Carminha Colaco, Bharathi Suresh +9 more
  Cellular and molecular life sciences : CMLS 2024 DOI: 10.1007/s00018-024-05187-2
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• βTrCP1 promotes SLC35F2 protein ubiquitination and inhibits cancer progression in HeLa cells.
  Jencia Carminha Colaco, Arun Pandian Chandrasekaran, Janardhan Keshav Karapurkar +9 more
  Biochemical and biophysical research communications 2023 DOI: 10.1016/j.bbrc.2023.09.095
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• E3 ubiquitin ligase APC/CCdh1 regulates SLC35F2 protein turnover and inhibits cancer progression in HeLa cells.
  Biochimica et biophysica acta. General subjects 2023 DOI: 10.1016/j.bbagen.2023.130454
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• USP19 Negatively Regulates p53 and Promotes Cervical Cancer Progression.
  Apoorvi Tyagi, Janardhan Keshav Karapurkar, Jencia Carminha Colaco +11 more
  Molecular biotechnology 2023 DOI: 10.1007/s12033-023-00814-y
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• CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis.
  Journal of experimental & clinical cancer research : CR 2023 DOI: 10.1186/s13046-023-02694-1
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• Phage engineering and phage-assisted CRISPR-Cas delivery to combat multidrug-resistant pathogens.
  Khushal Khambhati, Gargi Bhattacharjee, Nisarg Gohil +12 more
  Bioengineering & translational medicine 2022 DOI: 10.1002/btm2.10381
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• Dual role of deubiquitinating enzyme USP19 regulates mitotic progression and tumorigenesis by stabilizing survivin.
  Molecular therapy : the journal of the American Society of Gene Therapy 2022 DOI: 10.1016/j.ymthe.2022.07.019
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• Genome-wide screening for deubiquitinase subfamily identifies ubiquitin-specific protease 49 as a novel regulator of odontogenesis.
  Cell death and differentiation 2022 DOI: 10.1038/s41418-022-00956-7
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• The role of the CRISPR-Cas system in cancer drug development: Mechanisms of action and therapy.
  Biotechnology journal 2022 DOI: 10.1002/biot.202100468
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• Current approaches in CRISPR-Cas9 mediated gene editing for biomedical and therapeutic applications.
  Gargi Bhattacharjee, Nisarg Gohil, Khushal Khambhati +11 more
  Journal of controlled release : official journal of the Controlled Release Society 2022 DOI: 10.1016/j.jconrel.2022.02.005
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• Genome-Wide CRISPR/Cas9-Based Screening for Deubiquitinase Subfamily Identifies Ubiquitin-Specific Protease 11 as a Novel Regulator of Osteogenic Differentiation.
  International journal of molecular sciences 2022 DOI: 10.3390/ijms23020856
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• CYLD destabilizes NoxO1 protein by promoting ubiquitination and regulates prostate cancer progression.
  Saba Haq, Neha Sarodaya, Janardhan Keshav Karapurkar +6 more
  Cancer letters 2021 DOI: 10.1016/j.canlet.2021.10.032
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• Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells.
  International journal of molecular sciences 2021 DOI: 10.3390/ijms22115584
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• CRISPR-Cas9 based genome editing for defective gene correction in humans and other mammals.
  Progress in molecular biology and translational science 2021 DOI: 10.1016/bs.pmbts.2021.01.018
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• Disease modeling and stem cell immunoengineering in regenerative medicine using CRISPR/Cas9 systems.
  Computational and structural biotechnology journal 2020 DOI: 10.1016/j.csbj.2020.11.026
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• The Role of Deubiquitinating Enzymes in Hematopoiesis and Hematological Malignancies.
  Cancers 2020 DOI: 10.3390/cancers12051103
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