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Arun Pandian Chandrasekaran

King Abdullah University of Science and Technology, Hanyang University, Kumaraguru College of Technology, Indian Institute of Technology Guwahati, Government College of Technology

Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Ubiquitin and proteasome pathways · Cancer-related Molecular Pathways · Protein Degradation and Inhibitors

ORCID iD 0000-0003-2358-7345
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About

Arun Pandian Chandrasekaran is a stem cell biologist and researcher at King Abdullah University of Science and Technology (KAUST), specializing in modeling human embryogenesis using stem cell-based experimental systems. His primary research focuses on developing human blastoid models to investigate the molecular and cellular mechanisms underlying early human development.
His work integrates genome editing, single-cell transcriptomics, and advanced 3D culture systems to dissect lineage specification, cavitation, and implantation processes in vitro. He also explores how metabolic and microenvironmental factors influence embryo-like structure formation, with broader implications for understanding embryo quality and early developmental failure.
Beyond embryo modeling, Arun has interests in membrane biomechanics, optogenetic approaches to developmental control, and the application of multi-omics tools to study human-specific developmental biology. He maintains active collaborations with research groups across Saudi Arabia and the broader international scientific community.
His research aims to establish accessible, scalable, and ethically tractable platforms for studying human embryogenesis, with applications in regenerative medicine, fertility research, and the understanding of early developmental disorders.

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Publications (28)