Alexander Frankell

Employment

Employment history is unavailable.

Education

Education history is unavailable.

Projects & Funding

• Enabling non-invasive surveillance to measure and predict early cancer evolution Wellcome
  2025 - 2033

Publications (17)

• Harnessing genomics for early cancer detection, risk stratification and prevention
  Nature Genetics 2026 DOI: 10.1038/s41588-026-02505-1
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• Gene duplication is associated with gene diversification and potential neofunctionalization in lung cancer evolution
  Genome Research 2026 DOI: 10.1101/gr.278663.123
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• Clone copy number diversity is linked to survival in lung cancer
  Piotr Pawlik, Kristiana Grigoriadis, Abigail Bunkum

  +11 more

  • Helena Coggan
  • Alexander M. Frankell
  • Carlos Martínez‐Ruiz
  • Takahiro Karasaki
  • Ariana Huebner
  • +6 more
  Nature 2025 DOI: 10.1038/s41586-025-09398-w
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• Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER
  Nature Genetics 2025 DOI: 10.1038/s41588-024-01989-z
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• Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx
  Alexander M. Frankell, Michelle Dietzen, Maise Al Bakir +97 more
  Nature 2024 DOI: 10.1038/s41586-024-07738-w
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• Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling
  Sebastijan Hobor, Maise Al Bakir, Crispin T. Hiley +97 more
  Nature Communications 2024 DOI: 10.1038/s41467-024-47606-9
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• CONIPHER: a computational framework for scalable phylogenetic reconstruction with error correction
  Nature Protocols 2024 DOI: 10.1038/s41596-023-00913-9
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• Clonal Evolution in Healthy and Premalignant Tissues: Implications for Early Cancer Interception Strategies
  Cancer Prevention Research 2023 DOI: 10.1158/1940-6207.CAPR-22-0469
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• The evolution of lung cancer and impact of subclonal selection in TRACERx
  Alexander M. Frankell, Michelle Dietzen, Maise Al Bakir +97 more
  Nature 2023 DOI: 10.1038/s41586-023-05783-5
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• Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA
  Christopher Abbosh, Alexander M. Frankell, Thomas Harrison +97 more
  Nature 2023 DOI: 10.1038/s41586-023-05776-4
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• Body composition and lung cancer-associated cachexia in TRACERx
  Othman Al‐Sawaf, Jakob Weiss, Marcin Tomasz Skrzypski +97 more
  Nature Medicine 2023 DOI: 10.1038/s41591-023-02232-8
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• CONIPHER: a computational framework for scalable phylogenetic reconstruction with error correction
  2023 DOI: 10.21203/rs.3.pex-2158/v1
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• cloneMap: a R package to visualise clonal heterogeneity
  2022 DOI: 10.1101/2022.07.26.501523
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• Longitudinal tracking of 97 esophageal adenocarcinomas using liquid biopsy sampling
  Annals of Oncology 2021 DOI: 10.1016/j.annonc.2020.12.010
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• ctDNA in Gastric and Gastroesophageal Cancer: Prognostic, Predictive, or Preliminary?
  Clinical Cancer Research 2019 DOI: 10.1158/1078-0432.ccr-19-2774
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• The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic.
  Alexander M. Frankell, Sriganesh Jammula, Xiaodun Li +14 more
  Nature genetics 2019 DOI: 10.1038/s41588-018-0331-5
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• Genetics and Biomarkers in Barrett's Esophagus and Esophageal Adenocarcinoma
  Barrett's Esophagus: Emerging Evidence for Improved Clinical Practice 2016 DOI: 10.1016/B978-0-12-802511-6.00004-1
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