Hanuma kumar Karnati
University of Nebraska Medical Center College of Medicine
Research areas: Medicine · Neurology · Alzheimer's disease research and treatments · Traumatic Brain Injury Research · Traumatic Brain Injury and Neurovascular Disturbances
0000-0002-1259-6900
About
The goal of the proposed research is to develop novel biomarkers and therapeutics to understand drug mechanistic action in order to improve the treatment of cancer, neurodegenerative disorders like Parkinson’s disease, Alzheimer’s disease, and traumatic brain injury, and COVID 19 associated neurological disorders. This proposal also investigates identifying drugs that are therapeutically effective. Currently available biomarkers and drugs are not effective in diagnosis and treat cancer, neurodegenerative disorders, and COVID 19 associated neurological disorders. Therefore, the proposed studies are essential not only to understand the molecular mechanism of disease progression but also its potential utility for developing novel drugs.
I have the proven expertise, demonstrated leadership, and strong motivation necessary to successfully carry out the proposed research. I have an extensive background in molecular biology, drug development, biomarkers development, and therapeutics for cancer and neurodegenerative disorders. My research demonstrated that extracellular vesicle as a novel biomarker to assess the drug efficacy in clinical trials. In addition, as a post-doctoral fellow, I also have optimized several novel techniques to identify novel biomarkers to study the molecular mechanism of neurological disorders. I have successfully completed several projects which are related to Parkinson’s, Alzheimer’s, Traumatic brain injury and cancer at UIC, NIH, and UNMC, collaborated with other researchers. I have published 10 peerreviewed publications and one book chapter in high impact journals including JAMA Neurology, eLife, Translational psychiatry, and Tumor biology. I also working as a reviewer for several journals including Neural regeneration research, Cellular physiology and Biochemistry, Plos one, and Journal of Proteomics.
In summary, I have a strong demonstrated record of successful and productive research projects in areas of neurodegeneration and cancer. My research expertise in the neurological and cancer field is helpful to handle projects independently.
Employment
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University of Nebraska Medical Center College of Medicine2019 - Present
Education
Education history is unavailable.
Projects & Funding
Projects & funding information is unavailable.
Publications (11)
- Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury. Save
- Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease. Save
- Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease: A Secondary Analysis of the Exenatide-PD Trial. Save
- Neuronal Enriched Extracellular Vesicle Proteins as Biomarkers for Traumatic Brain Injury. Save
- Adiponectin as a Potential Therapeutic Target for Prostate Cancer. Save
- Neuroinflammation in animal models of traumatic brain injury. Save
- miRNAs: Key Players in Neurodegenerative Disorders and Epilepsy. Save
- microRNAs: Key Players in Hematopoiesis. Save
- TLR-4 signalling pathway: MyD88 independent pathway up-regulation in chicken breeds upon LPS treatment. Save
- Therapeutic potential of siRNA and DNAzymes in cancer. Save
- Down regulated expression of Claudin-1 and Claudin-5 and up regulation of β-catenin: association with human glioma progression. Save