Chandrashekhar Madasu

Employment

• Baylor College of Medicine
  2021 - Present

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (13)

• Identification of potent inhibitors of JUN N-terminal kinases for treatment of endometriosis and associated pain
  Chandrashekhar Madasu, Tirupataiah Sirupangi, Genesis J Herrera +22 more
  Proceedings of the National Academy of Sciences 2026 DOI: 10.1073/pnas.2607561123
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• Reversible male contraception by targeted inhibition of serine/threonine kinase 33
  Angela F. Ku, Kiran Lata Sharma, Hai Minh Ta +27 more
  Science 2024 DOI: 10.1126/science.adl2688
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• Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology
  Chandrashekhar Madasu, Zian Liao, Sydney E. Parks +14 more
  Proceedings of the National Academy of Sciences 2024 DOI: 10.1073/pnas.2322934121
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• Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening
  Journal of Medicinal Chemistry 2023 DOI: 10.1021/acs.jmedchem.2c01886
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• Microbial transformation of some triterpenoids of Guayule resin by Chaetomium sp.
  Phytochemistry Letters 2023 DOI: 10.1016/j.phytol.2023.05.001
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• Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A–C from guayule (Parthenium argentatum) resin
  Medicinal Chemistry Research 2022 DOI: 10.1007/s00044-021-02835-1
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• Cycloartane- and Lanostane-Type Triterpenoids from the Resin of Parthenium argentatum AZ-2, a Byproduct of Guayule Rubber Production
  ACS Omega 2021 DOI: 10.1021/acsomega.1c01714
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• Semi-Synthesis and Cytotoxicity Evaluation of Pyrimidine, Thiazole, and Indole Analogues of Argentatins A–C from Guayule (Parthenium Argentatum) Resin
  Research Square 2021 DOI: 10.21203/rs.3.rs-975607/v1
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• Synthesis and biological evaluation of some novel 1,2,3-triazole hybrids of myrrhanone B isolated from Commiphora mukul gum resin: Identification of potent antiproliferative leads active against prostate cancer cells (PC-3)
  Chandrashekhar Madasu, Shailaja Karri, Rajendra Sangaraju

  +2 more

  • Ramakrishna Sistla
  • Uppuluri Venkata Mallavadhani
  European Journal of Medicinal Chemistry 2020 DOI: 10.1016/j.ejmech.2019.111974
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• Design, synthesis, anti-inflammatory, cytotoxic and cell based studies of some novel side chain analogues of myrrhanones A & B isolated from the gum resin of Commiphora mukul
  Bioorganic Chemistry 2019 DOI: 10.1016/j.bioorg.2018.10.039
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• Synthesis and anti-inflammatory activity of some novel pyrimidine hybrids of myrrhanone A, a bicyclic triterpene of Commiphora mukul gum resin
  Monatshefte fur Chemie 2017 DOI: 10.1007/s00706-017-2024-7
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• Novel triazole hybrids of myrrhanone C, a natural polypodane triterpene: Synthesis, cytotoxic activity and cell based studies
  European Journal of Medicinal Chemistry 2016 DOI: 10.1016/j.ejmech.2016.03.013
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• Synthesis and anticancer activity of novel fused pyrimidine hybrids of myrrhanone C, a bicyclic triterpene of Commiphora mukul gum resin
  Molecular Diversity 2015 DOI: 10.1007/s11030-015-9621-3
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