Burkhard Poeggeler
Research areas: Neuroscience · Endocrine and Autonomic Systems · Circadian rhythm and melatonin · Alzheimer's disease research and treatments · Antioxidant Activity and Oxidative Stress
0000-0002-3927-1129
About
Poeggeler_2021_Agenda
Dr. Burkhard Poeggeler is affiliated with the Georg-August-University Göttingen and works on the biochemistry and pharmacology of regeneration by antioxidant protection and trophic prosurvival signaling. His research focusses on bioenergetic agents such as nitric oxide and on redox regulation such as neurovascular coupling. Neurovascular coupling drains the brain of waste for instance by facilitating the removal of the toxic amyloid peptides by the glymphatic system and the gastrointestinal tract. Together with many other distinguished scientists he investigates the unique nootropic, neurotrophic and neuroprotective activity of melatonin and related tryptophan metabolites based on their potent antioxidant, antiinflammatory antiamyloidogenic effects such as amyloid clearance by the glymphatic system, the connective tissue, the interstitium and the gastrointestinal tract. Based on the exploration of these protective agents, he works on developing new possibilities to extend human health and life span. His over 120 in PubMed listed publications demonstrate this wide range of his research activities covering important bioactive compounds that shape aging and development like melatonin, L-arginine and kynurenic acid.
Dr. Burkhard Poeggeler discovered that electron donation is a primary mechanism of radical detoxification in 1992 and he developed the first mechanistic SI system of radical reactions that allow for scavenging of these reactive intermediates to prevent their detrimental effects. The current SI system is largely dependent on his suggestions in 1995 to classify radical reactions according to their molecular mechanisms and not to their mediators. This once revolutionary approach has since then been successfully employed by many others in research on radical reactions and their biomolecular relevance for orchestrating the mitochondrial energy metabolism in all living beings. The decisive role of electron transfer in biomolecular reactions has since been extended to proton and photon transfer and can explain the unique adaptability and plasticity of organisms as open dissipative systems with high negentropy in evolution and development by photobiomodulation and exchange with the environment. His pioneer studies on neuroprotective compounds lead to the inaugural address to the president at the meeting of the Alzheimer´s Association in Philadelphia on new drug development in 2004 and has since then changed the view we look at agents that enable efficient detoxification, protection and regeneration. Bionic design inspired by nature can provide lead compounds with unprecedented bioavailability and bioactivity.
Dr. Burkhard Poeggeler has successfully orchestrated the development of potent nutraceuticals that allow for prevention and therapy. New approaches using unique biomatrix precision supplementation can assure healthy aging, prevent premature degeneration and greatly improve cognition. He works on holistic approaches that target the decisive molecular mechanisms and mediators of adaptation and aging by the applied sciences on nutrition. Amino acids are the building blocks of life that enable repair and regeneration of the body. The progressive increase in health care costs for non communicable diseases and the increase of morbidity and mortality with advanced age can be attributed to a great extend to the detelerious lack of appropriate sufficient bioenergetic support and the accumulative bioenergetic burden supposed upon the target population by the western diet that is rich in calories from sugar, fat and salt, but poor in nutrients and natural agents. The high prevalence of deleterious changes in the elderly is associated with a specific loss of redox regulation and regeneration that can prevent the age dependent degeneration, dedifferentiation and desynchronisation. Symbiosis and synchronisation determines successful supplementation and sustained health.
The process of metabolic adaptation and regulation induced by potent antioxidant bioenergetic agents can maintain health and improve cognition by targeting and enhancing cardiometabolic regulation and cardiovascular supply of bioenergetic resources. His research aims to maintain and improve stress resilience and restore regenerative sleep and symbiosis by a holistic healthcare that provides the decisive compounds for a superior metabolic regulation and permanent detoxification. Research on nutrients such as amino acids, peptides and proteins that can improve health at advanced age is a necessity. The future studies require a new research agenda which aims to identify and target the endogenous master regulators of adaptational plasticity and developmental physiology. The bioenergetic stimulation results in structural and functional changes that enable the appropriate responses of the body to any kind of demand and stress. The universal bioenergetic decline in aging can be targeted by a sufficient mitochondrial support.
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