AK
Antony Michealraj Kulandai Manuvel
Also known as: Michealraj KA, Michaelraj KA, Antony Michealraj, Antony Michaelraj, Antony Micheal
University of Pittsburgh, Hospital for Sick Children, University of Delhi, University of Madras
Research areas: Medicine · Oncology · Glioma Diagnosis and Treatment · Chromatin Remodeling and Cancer · Genomics and Chromatin Dynamics
0000-0002-3967-0816
Employment
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University of Pittsburgh Assistant Professor (Tenure-Track)2021 - Present
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Hospital for Sick Children Post Doctoral Fellow2014 - 2021
Education
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University of Delhi Ph.D2007 - 2014
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University of Madras MSc Biotechnology2005 - 2007
Projects & Funding
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Investigating genetic and targetable vulnerabilities of pediatric ependymomas by functional genomics Stanley M. Marks Blood Cancer Research Fund2025 - 2027
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Integrated epigenetic and metabolic regulation reveal targetable vulnerabilities in pediatric ependymomas V Foundation for Cancer Research2025 - 2026
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Metabolic and Therapeutic Vulnerabilities of Lethal Pediatric Ependymomas Matthew Larson Foundation for Pediatric Brain Tumors2023 - 2027
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Treating the Untreatable: Targeting Paediatric Brain Tumours with Multi-omics and Drug Discovery Mitacs2018 - 2020
Publications (26)
- Adenosylhomocysteinase drives epigenetic and metabolic reprogramming in ZFTA-RELA ependymoma Save
- A systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas Save
- Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma Save
- METTL3-IGF2BP3 m6A axis drives mutant huntingtin stability and neurodegeneration in Huntington’s disease Save
- Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma Save
- ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression Save
- ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip Save
- Protocol for the derivation of primary cancer stem cell lines from human ependymal tumors Save
- Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma Save
- An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma Save
- Epigenetically active chromatin in neonatal iWAT reveals GABPα as a potential regulator of beige adipogenesis Save
- TULIPs decorate the three-dimensional genome of PFA ependymoma Save
- 3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma Save
- Targeting mitochondrial energetics reverses panobinostat- and marizomib-induced resistance in pediatric and adult high-grade gliomas Save
- A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours Save
- A noncoding single-nucleotide polymorphism at 8q24 drives IDH1 -mutant glioma formation Save
- Pediatric posterior fossa ependymoma and metabolism: A narrative review Save
- Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma Save
- Hypoxia-induced epigenetic dysregulation promotes infantile ependymoma Save
- Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma Save