Sujith Joseph
Research areas: Medicine · Oncology · CAR-T cell therapy research · Cancer Immunotherapy and Biomarkers · Immunotherapy and Immune Responses
0000-0003-4596-1270
About
I am a scientist trained in human immunology of prophylactic and therapeutic interventions. With a PhD focused on understanding immune modulation on human and animal systems, I continued my research at University of Illinois (UIC) and National Institutes of Health (NIH) to identify and optimize vaccine candidates against infectious diseases based on naturally occurring protective immune responses in endemic populations. Currently, at the Center for cell and gene therapy of Baylor College of Medicine and Texas Children’s Hospital Cancer and Hematology Center, I conduct translational research with gene-modified T-cells to treat solid tumors in children and young adults. My focus is on pre-clinical development of novel Chimeric Antigen Receptor (CAR) molecules and delineating immune correlates in patients undergoing CAR T-cell therapy in clinical trials.
Employment
Employment history is unavailable.
Education
Education history is unavailable.
Projects & Funding
-
Developing Sarcoma-specific T-cell Platform for Grafting Chimeric Antigen Receptors The Faris Foundation2019 - Present
Publications (26)
- Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells Save
- A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma Save
- General principles of cellular immunotherapy Save
- Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma. Save
- Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma. Save
- CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression. Save
- CAR T-Cell Therapy for CNS Malignancies Save
- Chimeric antigen receptor T-cells for glioblastoma: The journey ahead Save
- A homing system targets therapeutic T cells to brain cancer Save
- Response to the comment on "trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma" by Bielamowicz et al Save
- Trivalent CAR T-cells Overcome Interpatient Antigenic Variability in Glioblastoma Save
- Cross reactive molecules of human lymphatic filaria Brugia malayi inhibit Leishmania donovani infection in hamsters Save
- Protection against filarial infection by 45-49 kDa molecules of Brugia malayi via IFN-γ-mediated iNOS induction Save
- Humoral and cell-mediated immune responses elicited by poly (dl-lactide) adjuvanted filarial antigen molecules Save
- Anti-inflammatory BmAFI of Brugia malayi modulates IgE, histamine and histamine receptor responses in Mastomys coucha Save
- Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis Save
- IgG subclass responses to proinflammatory fraction of Brugia malayi in human filariasis Save
- Protective immune responses to biolistic DNA vaccination of Brugia malayi abundant larval transcript-2 Save
- Plant products in the treatment and control of filariasis and other helminth infections and assay systems for antifilarial/anthelmintic activity Save
- Sensitization with anti-inflammatory BmAFI of Brugia malayi allows L3 development in the hostile peritoneal cavity of Mastomys coucha Save