Siva sankari Sivasoorian

About

I am Dr. Siva Sankari Sivasoorian, a biomedical scientist specializing in nanomedicine, nucleic acid therapeutics, and analytical biophysics. I recently completed my postdoctoral research at Wayne State University, where I developed organ-specific lipid nanoparticles (OSLNPs) for CRISPR/Cas9 delivery targeting cardiovascular and skin disorders.

My research journey spans the design and characterization of advanced nanocarriers—including DNA nanostructures, lipid nanoparticles, and gold-based platforms—for targeted drug and gene delivery. Previously, at National Tsing Hua University in Taiwan, I engineered ligand-functionalized carbon dot liposomes for immune checkpoint blockade and developed orthotopic breast cancer models.

I hold a Ph.D. in Medicinal and Applied Chemistry from Kaohsiung Medical University, Taiwan, where my work focused on nanocarrier systems for photothermal cancer therapy and antimicrobial interventions. My expertise encompasses nanoparticle synthesis, photothermal therapy, cell and animal model studies, and a wide range of analytical and molecular biology techniques.

My publications appear in journals such as Pharmaceutics, Colloids and Surfaces B: Biointerfaces, ACS Applied Bio Materials, and Journal of Materials Chemistry B. I actively contribute as a peer reviewer for scientific journals and have been recognized with awards including the Outstanding Research Award from Wayne State University.

My long-term goal is to advance tissue-specific nanoparticle delivery systems for gene therapy, with a focus on translational applications to treat rare and complex diseases.

Employment

Employment history is unavailable.

Education

• Kaohsiung Medical University Doctor of Philosophy
  2016 - 2022

Projects & Funding

• • Ministry of Science and Technology of Taiwan grant MOST109-2320-B-037-017-MY3 Ministry of Science and Technology, Taiwan
• Ministry of Science and Technology of Taiwan grant MOST108-2221-B-037-002-MY3 Ministry of Science and Technology, Taiwan
• Kaohsiung Medical University grant Kaohsiung Medical University

Publications (7)

• Nanotechnology-Based Delivery of CRISPR/Cas9 for Cancer Treatment: A Comprehensive Review
  Cells 2025
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• Comparing the Variants of Iron Oxide Nanoparticle-Mediated Delivery of miRNA34a for Efficiency in Silencing of PD-L1 Genes in Cancer Cells
  Pharmaceutics 2023 DOI: 10.3390/pharmaceutics15010215
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• Neuropeptide-Functionalized Gold Nanorod Enhanced Cellular Uptake and Improved In Vitro Photothermal Killing in LRP1-Positive Glioma Cells.
  Pharmaceutics 2022 DOI: 10.3390/pharmaceutics14091939
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• Comparative study of an antimicrobial peptide and a neuropeptide conjugated with gold nanorods for the targeted photothermal killing of bacteria
  Colloids and Surfaces B: Biointerfaces 2021 DOI: 10.1016/j.colsurfb.2021.112117
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• Near-Infrared Light-Triggered Drug Release from Ultraviolet- And Redox-Responsive Polymersome Encapsulated with Core-Shell Upconversion Nanoparticles for Cancer Therapy
  ACS Applied Bio Materials 2021 DOI: 10.1021/acsabm.0c01621
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• Rapid synthesis of a novel nano-crystalline mesoporous faujasite type metal-organic framework, ZIF-8 catalyst, its detailed characterization, and NaBH4 assisted, enhanced catalytic Rhodamine B degradation
  Suman Chirra, Li‐Fang Wang, Himanshu Aggarwal +6 more
  Materials Today Communications 2021 DOI: 10.1016/j.mtcomm.2020.101993
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• Synthesis of new multivalent metal ion functionalized mesoporous silica and studies of their enhanced antimicrobial and cytotoxicity activities
  Suman Chirra, Suresh Siliveri, Gangalla Ravi +7 more
  Journal of Materials Chemistry B 2019 DOI: 10.1039/c9tb01736d
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