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Xuankuo Xu
Bristol-Myers Squibb Co, University of Delaware
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Protein purification and stability · Monoclonal and Polyclonal Antibodies Research · Viral Infectious Diseases and Gene Expression in Insects
0000-0002-5557-0284
Employment
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Bristol-Myers Squibb Co Director2008 - Present
Education
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University of Delaware Ph.D.2002 - 2008
Projects & Funding
Projects & funding information is unavailable.
Publications (51)
- High-throughput microscale chromatography for process characterization and control strategy development in biologics manufacturing Save
- Flow-through polishing of Protein A eluates: Removal of high and low molecular weight impurities by size-exclusion-mixed-mode chromatography Save
- Hydrophobicity analysis of Chinese Hamster Ovary host cell proteins using analytical hydrophobic interaction chromatography and LC-MS Save
- Modeling and techno-economic analysis of downstream manufacturing process intensification strategies for existing biopharmaceutical facilities Save
- Predictive mechanistic modeling of loading and elution in protein A chromatography Save
- Behavior of host-cell-protein-rich aggregates in antibody capture and polishing chromatography Save
- Analytical characterization of host‐cell‐protein‐rich aggregates in monoclonal antibody solutions Save
- Comparison of host cell protein removal by depth filters with diatomaceous earth and synthetic silica filter aids using model proteins Save
- Engineering protein A ligands to mitigate antibody loss during high-pH washes in protein A chromatography Save
- Role of the gradient slope during the product internal recycling for the multicolumn countercurrent solvent gradient purification of PEGylated proteins Save
- Effect of solution condition on the binding behaviors of monoclonal antibody and fusion protein therapeutics in Protein A chromatography Save
- Role of harvest depth filtration in controlling product-related impurities for a bispecific antibody Save
- Virus inactivation at moderately low pH varies with virus and buffer properties Save
- Continued insights into virus clearance validation across continuous capture chromatography Save
- Productivity improvement and charge variant modulation for intensified cell culture processes by adding a carboxypeptidase B (CpB) treatment step Save
- Experimental Design of the Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) Unit for the Separation of PEGylated Proteins Save
- Physiochemical properties of enveloped viruses and arginine dictate inactivation Save
- Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction Save
- A CFD model for predicting protein aggregation in low‐pH virial inactivation for mAb production Save
- Hydrophobic property of cation-exchange resins affects monoclonal antibody aggregation Save